- ￥17200 - 29500
- TargetMol
- 美国
- T69221
- 2025年07月15日
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- 文献和实验
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
BMS-554417
- 库存：
10
- 供应商：
TargetMol
- CAS号：
468741-42-6
- 规格：
25 mg/50 mg/100 mg
| 规格： | 25 mg | 产品价格： | ￥17200.0 |
|---|---|---|---|
| 规格： | 50 mg | 产品价格： | ￥22800.0 |
| 规格： | 100 mg | 产品价格： | ￥29500.0 |
Product Introduction
Bioactivity
英文名:BMS-554417
描述:BMS-554417 is a novel inhibitor of IGF-IR, which inhibits IGF-IR and insulin receptor kinase activity and proliferation in vitro, and reduces tumor xenograft size in vivo. In a series of carcinoma cell lines, the IC50 for proliferation ranged from 120 nmol/L (Colo205) to >8.5 micromol/L (OV202). BMS-554417 treatment inhibited IGF-IR and insulin receptor signaling through extracellular signal-related kinase as well as the phosphoinositide 3-kinase/Akt pathway, as evidenced by decreased Akt phosphorylation at Ser473. At doses that inhibited proliferation, the compound also caused a G0-G1 arrest and prevented nuclear accumulation of cyclin D1 in response to LR3 IGF-I. In Jurkat T-cell leukemia cells, this agent triggered apoptotic cell death via the mitochondrial pathway. BMS-554417 was orally bioavailable and significantly inhibited the growth of IGF1R-Sal tumor xenografts in vivo. BMS-554417 is a member of a novel class of IGF-IR/insulin receptor inhibitors that have potential......
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Combined Chromatin Immunoprecipitation and Bisulfite Methylation Sequencing Analysis
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