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AJE 润色服务限时 8 折起，权威机构信任 15+ 年Cytoscape 教程来了！快速实现顶刊同款通路网络图五大应用案例：Mustang Q 膜层析应用全解析1 个小工具，一次性搞定流程图、质粒图谱和信号通路图- 详细信息
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- 技术资料
- 保存条件：
零下20℃
- 保质期：
至少一年有效
- 英文名：
FMR1 autosomal homolog 2
- 库存：
现货
- 供应商：
上海经科化学科技有限公司
- 规格：
5µg
pLenti-FXR2-sgRNA (FXR2基因敲除质粒)是一种在动物细胞中可以同时表达Cas9、目的基因的sgRNA和puromycin抗性基因的质粒。用于在动物细胞中直接基于CRISPR/Cas9技术敲除目的基因，或者通过包装慢病毒后基于CRISPR/Cas9技术敲除目的基因。本质粒中sgRNA的有效性已经通过T7EI法的验证。
本质粒在细菌中为Amp抗性，全长约13,000bp。本质粒的关键图谱信息请参考图1。本质粒可直接转染细胞用于目的基因的CRISPR/Cas9敲除，以及通过puromycin筛选稳定细胞株；也可以与pMDLg、Rev及VSV-g共转HEK293T细胞进行重组慢病毒(lentivirus)的包装，然后再用于感染细胞或组织并进行目的基因的CRISPR/Cas9敲除。
图1. 表达sgRNA、Cas9和puromycin抗性的pLenti-sgRNA质粒关键图谱信息。
FXR2基因的基本信息如下：
| Species | Gene Symbol | Gene ID | GenBank Accession | Transcript |
| Human | FXR2 | 9513 | BC020090 | NM_004860 |
| About the gene | |
| Official Symbol | FXR2 |
| Previous Symbol | FMR1L2 |
| Official Full Name | FMR1 autosomal homolog 2 |
| Synonyms | - |
| Location | 17p13.1 |
| Gene Type | protein-coding gene |
| Uniprot ID | P51116 |
| Pathway/Library | Epigenetic Regulators Related Genes Library |
| Gene Summary | The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome. |
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