AS-2077715

真菌复合物III的抑制剂（对于须癣毛癣菌复合物III，IC50=80ng/ml）；对真菌的选择性优于哺乳动物复合物III（对于小鼠EL-4细胞和人类Jurkat细胞复合物III，IC50分别为480和860ng/ml）；抑制ATP产生（IC50=0.33µg/ml），在1和10µg/ml浓度下对须癣毛癣菌具有杀菌作用；在10和20mg/kg浓度下，减少豚鼠须癣毛癣菌感染模型中脚垫皮肤的菌落形成单位数量。An inhibitor of fungal complex III (IC50 = 80 ng/ml for T. mentagrophytes complex III); selective for fungal over mammalian complex III (IC50s = 480 and 860 ng/ml for murine EL-4 cell and human Jurkat cell complex III, respectively); inhibits ATP production in (IC50 = 0.33 µg/ml) and is fungicidal against T. mentagrophytes at 1 and 10 µg/ml; reduces the number of foot pad skin CFUs in a guinea pig model of T. mentagrophytes infection at 10 and 20 mg/kg.