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IL-13 (Ser26-Phe131, C-6His),

Mouse, Recombinant
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  • ¥1780 - 35580
  • 普诺赛
  • PCK253
  • 国产
  • 2025年07月30日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 库存

      现货

    • 供应商

      上海经科化学科技有限公司

    • 规格

      50μg/10μg/1mg/500μg

    规格:50μg产品价格:¥4980.0
    规格:10μg产品价格:¥1780.0
    规格:1mg产品价格:¥35580.0
    规格:500μg产品价格:¥24080.0

    产品信息

    别名 Interleukin-13; IL-13; T-Cell Activation Protein P600; Il13; Il-13
    物种 Mouse
    表达宿主 Human Cells
    序列信息 Ser26-Phe131
    检索号 P20109
    分子量 12.7 kDa
    表观分子量 15-30 kDa
    标签 C-6His
    生物活性 Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED50 for this effect is 2-13 ng/ml.

    产品特性

    纯度 >95% as determined by reducing SDS-PAGE.
    内毒素 <1.0 EU per µg as determined by LAL test.
    保存 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
    运输 Ambient temperature or ice pack.
    制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

    背景介绍

    Mouse Interleukin 13 (mIL-13) is a pleiotropic Cytokine produced by activated Th2 cells. IL-13 induces B cell proliferation and immunoglobin production. It contains a four helical bundle with two internal disulfide bonds. Mouse IL13 shares 58% sequence identity with human Protein and exhibits cross-species activity. IL13 signals via Receptor IL13R (type2, IL4R) and activates STAT-6. IL13 initially binds IL-13Rα1 with low affinity and triggers association of IL4Rα, generating a high affinity heterodimeric Receptor IL13R and eliciting downstream signals. IL13 also binds IL-13Rα2 with high affinity, which plays a role in a negative feedback system of IL13 signaling. IL13 is an important mediator of allergic inflammation and disease.

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    ¥1780 - 35580