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huayun / IL-13 (Ser26-Phe131,

C-6His), Mouse, Recombinant,HYPC5250
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  • ¥5340
  • 华韵生物(Huayunbio)
  • HYPC5250
  • 2025年07月16日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 供应商

      广州华韵生物科技有限公司

    • 规格

      10µg

    产品信息

    别名Interleukin-13; IL-13; T-Cell Activation Protein P600; Il13; Il-13
    物种Mouse
    表达宿主Human Cells
    序列信息Ser26-Phe131
    检索号P20109
    分子量12.7 kDa
    表观分子量15-30 kDa
    标签C-6His
    生物活性 Measured in a cell proliferation assay using TF‑1 human erythroleukemic cellsThe ED50 for this effect is less than 5 ng/ ml.

    产品特性

    纯度 >95% as determined by reducing SDS-PAGE.
    内毒素< 1.0 EU per µg as determined by LAL test.
    保存 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2~8℃ for 2~7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
    运输 Ambient temperature or ice pack.
    制剂Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    复融Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

    背景介绍

    Mouse Interleukin 13 (mIL-13) is a pleiotropic Cytokine produced by activated Th2 cells. IL-13 induces B cell proliferation and immunoglobin production. It contains a four helical bundle with two internal disulfide bonds. Mouse IL13 shares 58% sequence identity with human Protein and exhibits cross-species activity. IL13 signals via Receptor IL13R (type2, IL4R) and activates STAT-6. IL13 initially binds IL-13Rα1 with low affinity and triggers association of IL4Rα, generating a high affinity heterodimeric Receptor IL13R and eliciting downstream signals. IL13 also binds IL-13Rα2 with high affinity, which plays a role in a negative feedback system of IL13 signaling. IL13 is an important mediator of allergic inflammation and disease.

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