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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
peptide
- 亚型:
IgG1
- 形态:
Liquid
- 保存条件:
-20℃
- 克隆性:
mAb
- 适应物种:
Human
- 保质期:
1年
- 目录编号:
TD-31411
- 级别:
科研级
- 库存:
88
- 供应商:
武汉天德
- 宿主:
Mouse
- 应用范围:
FCM、ELISA
- 靶点:
详询
- 抗体英文名:
Mouse Monoclonal Antibody to CD11C
- 抗体名:
CD11C
- 规格:
100ul/50ul
| 规格: | 100ul | 产品价格: | ¥2180.0 |
|---|---|---|---|
| 规格: | 50ul | 产品价格: | ¥1280.0 |
Mouse Monoclonal Antibody to CD11C
Description |
|
| This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. | |
Specification |
|
| Aliases | ITGAX; SLEB6 |
| Entrez GeneID | 3687 |
| Swissprot | P20702 |
| clone | 6G2D1 |
| WB Predicted band size | 127.8kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD11C (AA: extra 102-279) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
Application |
|
| FCM | 1/200 - 1/400 |
| ELISA | 1/10000 |
Product Image |
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文献和实验Defining In Vivo Dendritic Cell Functions Using CD11c-DTR Transgenic Mice
context. To this end we have developed a conditional cell ablation strategy that is based on dendritic cell-restricted expression of a Diphtheria Toxin receptor (DTR) using the CD11c/Itgax promoter. Here, we provide basic protocols that describe the use
CD11a/CD11b/CD11c 分子 CDlla 常用单克隆抗体或代号:MHM24, 2F12; CRIS―3(LFA―lα链,整合素α1) 主要表达细胞:Leu[A5] 分子质量(kDa)和结构:spl80(整合素α) 功 能:与1CAM-l(CD54)、ICAM-2(CDl02)、ICAM-3(C1350)结合,介导细胞黏附;与JAMl结合,参与白细胞穿过内皮细胞
Nature Medicine 再论多重免疫荧光揭示预测性生物标志物,用于优化免疫治疗临床试验设计
特征和生存率间关系 在 TLS 结构之外,治疗应答者和非应答者之间最显著差异表达的基因是那些编码免疫球蛋白,特别是免疫球蛋白 G(IgG)的基因。多色免疫荧光标记肿瘤内的 CD83、CD1c、CD11c、CD68、HLA-DRA、DAPI 对比应答者和非应答者的 TLS,显示非应答者中幼稚 B 细胞的浸润程度更高。 多重免疫荧光验证抗原呈递细胞肿瘤浸润与 TLS 阳性肉瘤患者的抗 PD-1 反应有关 为了可视化应答者和非应答者之间免疫细胞丰度的差异,研究者开发了三个六色免疫荧光方案,能够
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