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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
A synthesized peptide derived from human CD74
- 亚型:
IgG
- 形态:
Liquid
- 保存条件:
-20℃
- 克隆性:
pAb
- 适应物种:
Human
- 保质期:
1年
- 目录编号:
TD-381689
- 级别:
科研级
- 库存:
88
- 供应商:
武汉天德
- 宿主:
Rabbit
- 应用范围:
WB,IHC-P,ICC/IF,FC
- 靶点:
详询
- 抗体英文名:
CD74
- 抗体名:
CD74
- 规格:
100ul/50ul
| 规格: | 100ul | 产品价格: | ¥1090.0 |
|---|---|---|---|
| 规格: | 50ul | 产品价格: | ¥1980.0 |
|
Product Name
|
CD74 Rabbit pAb
|
|
Gene ID
|
972
|
|
SwissProt ID
|
P04233
|
|
Gene Name
|
CD74
|
|
Alternative Names
|
CD74; DHLAG; HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain; Ia antigen-associated invariant chain; Ii; p33; CD74
|
|
Background
|
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place.
|
|
Research Field
|
Immunology
|
|
Product Categories
|
Primary antibody
|
|
Host
|
Rabbit
|
|
Reactivity
|
Human
|
|
Application
|
WB,IHC-P,ICC/IF,FC
|
|
Cited
|
WB (Pig)
|
|
Dilution Ratio
|
WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 FC: 1/50-1/100
|
|
Molecular Weight
|
Calculated MW: 34 kDa; Ob/served MW: 34 kDa
|
|
Clonality
|
Polyclonal Antibody
|
|
Clonality No.
|
-
|
|
Isotype
|
IgG
|
|
Immunogen
|
A synthesized peptide derived from human CD74
|
|
Purification
|
Affinity Chromatography
|
|
Conjugation
|
Unconjugated
|
|
Modification
|
Unmodified
|
|
Form
|
Liquid
|
|
Buffer System
|
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
|
|
Storage
|
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
|
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文献和实验CD74 分子 CD74 常用单克隆抗体或代号: LN2,BU- 43;(li,lg ) 主要表达细胞: B,Msub [B] 分子质量(kDa)和结构: gp41/35/33,Ⅱ类相关恒定链(li链) 功 能: 与新合成MHCⅡ类分子结合,防止MHC结合内源肽 CD74 Gamma chain antigen associated with MHC class II antigen
的发挥需与多种胞内蛋白相互作用,而这首先需要MIF信号的跨膜传递。克隆表达和功能分析发现CD74是MIF的高亲合力膜结合蛋白,起着MIF跨膜受体的作用。在重组可溶性CD74分子,MIF结合于其109-149氨基酸残基部位,从而活化胞外MAPK信号传导、细胞增殖分化和前列腺素E2的产生[3]。 2.2 对糖皮质激素(GC)作用的调节 2.2.1 cPLA2机制 胞浆磷脂酶A2(cPLA2)及其活化后产物花生四烯酸是炎症反应的重要调节因子。GC以cPLA2为目标
主要特异性 CD T CD1- CD8 、 CD27 、 CD28 、 CD99 、 CD99R 、 CD152- CD154 B CD10 、 CD19- CD24 、 CD37- CD40 、 CD72- CD74 、 CDw75
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