CD74分子
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CD74 分子
CD74
常用单克隆抗体或代号： LN2,BU- 43;(li,lg )
主要表达细胞： B,Msub [B]
分子质量(kDa)和结构： gp41/35/33,Ⅱ类相关恒定链(li链)
功 能： 与新合成MHCⅡ类分子结合,防止MHC结合内源肽
CD74
Gamma chain antigen associated with MHC class II antigen
In synthesis of class II antigens of MHC, newly synthesized alpha and beta chains form stable complex with gamma chains in the endoplasmic reticulum; then transported to Golgi, where gamma chain dissociates
Positive staining (normal): B-cells, activated T-cells, macrophages, activated endothelial and epithelial cells
