重组人鼠鼠鸢尾素

重组人鼠鼠鸢尾素 英文名称：Recombinant Human/Murine/Rat Irisin 规格：2ug 价格：￥1,128 货号：100-65-2ug RUO PROTEINS Irisin is a proteolytic hormone released into circulation by skeletal muscle tissue during acute exercise, and is a derivative of the cleaved plasma membrane protein Fibronectin type III domain-containing protein 5 (FNDC5). Found in muscle tissue, FNDC5 is synthesized at increased levels during exercise as a result of the overexpression of the exercise-responsive transcriptional co-activator PGC-1α (peroxisome proliferator-activated receptor-γ co-activator-1α). Like its parent polypeptide, Irisin can induce the browning of subcutaneous adipocytes, or the conversion of white adipose tissue (WAT or white fat) into brown (or beige) adipose tissue (BAT or brown fat). Given that brown fat can undergo thermogenesis, or the physiologic process of heat production, Irisin contributes to the metabolic process by increasing thermogenic function and glucose homeostasis. Irisin, thus, represents a link between exercise and “burning” of fats and/or sugars, and consequently may have relevance in the development of new treatments for diabetes and obesity. CHO cell-derived Recombinant Human/Murine/Rat Irisin is a glycosylated homodimer of 224 amino acid residues, whose monomer consists of 112 amino acid residues corresponding to the active portion of the 121-amino-acid length Irisin extracellular domain. Recombinant Human/Murine/Rat Irisin, appears to form a non-disulfide linked oligomeric structure in solution, has a calculated theoretical molecular weight of 25.2 kDa, but migrates at an apparent molecular weight of 28 kDa by SDS-PAGE analysis under reducing conditions due to glycosylation. Source: CHO cells Synonyms: Fibronectin type III domain-containing protein 5 (FNDC5), Fibronectin type III repeat-containing protein 2 (FRCP2) AA Sequence (monomer): DSPSAPVNVT VRHLKANSAV VSWDVLEDEV VIGFAISQQK KDVRMLRFIQ EVNTTTRSCA LWDLEEDTEY IVHVQAISIQ GQSPASEPVL FKTPREAEKM ASKNKDEVTM KE Purity: ≥ 90% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to promote cell survival and growth of rat H9c2 cardio-myoblasts under serum starvation conditions. Calculated Molecular Weight: 25.2 kDa Accession Number: Q8NAU1 Gene ID: 252995 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Human, Mouse, Rat重组人鼠鼠鸢尾素 是齐一生物公司重点推广产品，齐一生物代理PeproTech的产品原装正品质量，我公司有专业的人员进行全程指导，请放心购买、发货时均会附上质检报告单、使用说明书和推荐用法用量、提供正规发票欢迎来电咨询！ PeproTech于1988年创立于美国，Peprotech的产品具有很高的性价比，这些细胞因子应用于生命科学研究；在众多高水平的实验室和研究机构中广泛使用。截至2013年底，已被13,000篇SCI文献引用；取得了细胞因子产品领域居于地位。 PeproTech重组蛋白与科学服务领域是由经验丰富的蛋白质科学家开发出来的，因此能够为制备抗体提供高品质的原料。重组蛋白到抗原亲和纯化的抗体拥有自己的研发系统，能够保证产品的高品质。