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Granzyme B Mouse mAb(bsm-34135

M)-50ul/100ul
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  • ￥1180 - 1980
  • Bioss已认证
  • bsm-34135M
  • 2025年10月24日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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      50ul/100ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    产品编号bsm-34135M
    英文名称Granzyme B Mouse mAb
    中文名称颗粒酶B单克隆抗体
    英文别名GranzymeB; Granzyme-B; C11; Cathepsin G-like 1; CTLA-1; Cathespin G Like 1; CCPI; CCP-1; CGL 1; CGL1; CSP B; CSPB; CTLA 1; CTLA1; CTSGL 1; CTSGL1; Cytotoxic serine protease B; Cytotoxic T Lymphocyte Associated Serine Esterase 1; Cytotoxic T lymphocyte proteinase 2; Fragmentin 2; Fragmentin2; Granzyme 2; Granzyme2; GRB; GZMB; Cytotoxic T-lymphocyte proteinase 2; Fragmentin-2; GRAB_HUMAN; Granzyme B(granzyme 2, cytotoxic T lymphocyte associated serine esterase 1); Granzyme B; Granzyme-2; GranzymeB; HLP; T cell serine protease 1 3E; T cell serine protease 1-3E; T-cell serine protease 1-3E; HLP; Human lymphocyte protein; Lymphocyte protease; Protease Serine B; SECT; AA 18-29; T cell serine protease 1.
    产品应用IHC-P=1:200-1000, IHC-F=1:200-1000, IF=1:200-1000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human
    抗体来源Mouse
    免疫原KLH conjugated synthetic peptide derived from human Granzyme B
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Monoclonal
    理论分子量25 kDa
    浓度1mg/ml
    储存液0.02% Proclin300, 0.5% BSA, 50% Glycerol.
    研究领域

    Cell Biology > Apoptosis > Extracellular Signals > Granzymes

    Immunology > Adaptive Immunity > Regulatory T Cells

    Immunology > Adaptive Immunity > T Cells > Cytotoxic Cells

    Immunology > Innate Immunity > NK Cells

    亚细胞定位Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.
    相似性Belongs to the peptidase S1 family. Granzyme subfamily.
    Contains 1 peptidase S1 domain.
    功能This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料

    Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. [provided by RefSeq, Jul 2008]

     

    应用推荐稀释比例
    {IHC-P}{1:200-1000}
    {IHC-F}{1:200-1000}
    {IF}{1:200-1000}

     

    产品细节图片1
    P‌‌araformaldehyde-fixed, paraffin embedded Human Colon Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Granzyme B Monoclonal Antibody, Unconjugated(bsm-34135M) at 1:200 overnight at 4°C, followed by conjugation to the bs-40296G-HRP and DAB (C-0010) staining.
    产品细节图片2
    P‌‌araformaldehyde-fixed, paraffin embedded Human Tonsil; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Granzyme B Monoclonal Antibody, Unconjugated(bsm-34135M) at 1:200 overnight at 4°C, followed by conjugation to the bs-40296G-HRP and DAB (C-0010) staining.
    产品细节图片3
    P‌‌araformaldehyde-fixed, paraffin embedded Human Lung; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Granzyme B Monoclonal Antibody, Unconjugated(bsm-34135M) at 1:200 overnight at 4°C, followed by conjugation to the bs-40296G-HRP and DAB (C-0010) staining.
    产品细节图片4
    P‌‌araformaldehyde-fixed, paraffin embedded Human Colon; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Granzyme B Monoclonal Antibody, Unconjugated(bsm-34135M) at 1:200 overnight at 4°C, followed by conjugation to the bs-40296G-HRP and DAB (C-0010) staining.
    产品细节图片5
    P‌‌araformaldehyde-fixed, paraffin embedded Human Spleen; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Granzyme B Monoclonal Antibody, Unconjugated(bsm-34135M) at 1:200 overnight at 4°C, followed by conjugation to the bs-40296G-HRP and DAB (C-0010) staining.

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    [IF={{ 3.3 }}] {Jiayun Jiang. et al. The immune-reinforcements of Lenvatinib plus anti-PD-1 and their rationale to unite with TACE for unresectable hepatocellular carcinoma treatment. IMMUNOL LETT. 2025 Oct;275:107003} {IF} {Human,Mouse}

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    文献支持
    Granzyme B Mouse mAb(bsm-34135M)-50ul/100ul
    ￥1180 - 1980