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文献和实验Detection of Noncollagenous Bone Proteins in Methylmethacrylate-Embedded Human Bone Sections
, including osteocalcin, osteopontin, osteonectin, bone sialoprotein, decorin, and biglycan. Of this group only osteocalcin and bone sialoprotein are specific for bone, whereas the other proteins are also present in other, noncalcifying, tissues. The knowledge
Isolation and Culture of Bone-Forming Cells (Osteoblasts) from Human Bone
The most conspicuous function of the osteoblast is the formation of bone. During phases of active bone formation, osteoblasts synthesize bone matrix and prime it for subsequent mineralization. Active osteoblasts are plump, cuboidal cells rich
In Vivo Models of Human Prostate Cancer Bone Metastasis
(1 ). Much of the morbidity and mortality associated with prostate cancer is the result of its progression to distant metastasis, particularly to bone: more than 70% of patients present at autopsy with bone metastases (2 ,3 ). These lesions are usually osteoblastic
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