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PeproTech Murine IL-4 (20ug)

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  • 214-14-20UG
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  • 2026年03月03日
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    • 供应商：

      PeproTech(派普泰克)

    • 英文名：

      Recombinant Murine IL-4

    • 规格：

      20ug

    现货供应
     
     
    Recombinant Murine IL-4
    IL-4 是一种多效性细胞因子，可调控多种 T 细胞和 B 细胞应答，包括细胞增殖、存活及基因表达。IL-4 主要由肥大细胞、T 细胞和骨髓基质细胞产生，能够调控初始 CD4+ T 细胞分化为 Th2 辅助细胞。Th2 细胞的特征为分泌特定细胞因子谱，包括 IL-4、IL-5、IL-6、IL-10 和 IL-13，主要介导体液免疫应答。
     
    IL-4 的另一主要功能是调控免疫球蛋白类别转换，诱导产生 IgG1 和 IgE 亚型。Th2 细胞过量产生 IL-4 与 IgE 水平升高及过敏反应相关。
     
    重组小鼠 IL-4 是一种 13.5 kDa 的球状蛋白，含有 121 个氨基酸残基。
     
    来源：大肠杆菌
     
    别名：BCGF、BCDF、B 细胞刺激因子（BSF-1）
     
    氨基酸序列：
     
    MHIHGCDKNH LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK KNSSVLMELQ RLFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S
     
    纯度：经 SDS‑PAGE 与 HPLC 检测，纯度 ≥ 98%
     
    生物学活性：
     
    采用小鼠 HT‑2 细胞的剂量依赖性增殖实验测定 ED50 ≤ 2.0 ng/ml，对应比活性 ≥ 5×10⁵ 单位 /mg。
     
    本品已按照 WHO 标准进行标定，国际单位信息可查阅相关文件。
     
    计算分子量：13.5 kDa
     
    登录号：P07750
     
    基因 ID：16189
     
    内毒素：内毒素水平 ＜ 0.1 ng/μg 蛋白（＜ 1 EU/μg）
     

    IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant Murine IL-4 is a 13.5 kDa globular protein containing 121 amino acid residues.

    Source:E.coli

    Synonyms:BCGF, BCDF, B cell stimulating factor (BSF-1)

    AA Sequence:MHIHGCDKNH LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK KNSSVLMELQ RLFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S

    Purity:≥ 98% by SDS-PAGE gel and HPLC analyses.

    Biological Activity:The ED50 was determined by the dose-dependent proliferation of murine HT-2 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

    This product has been tested against the WHO standard. International Unit information can be found 

    Calculated Molecular Weight:13.5 kDa

    Accession Number:P07750

    Gene ID:16189

    Endotoxin:Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

     

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      PeproTech Murine IL-4 (20ug)
      ￥1719