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- 供应商：
gibco
- 库存：
充足
- 英文名：
Human Noggin Recombinant Protein
- 规格：
500μg
Human Noggin Recombinant Protein（500UG）
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Product Details |
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Size |
500 µg |
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Species |
Human |
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Published Species |
Dog, Pig, Rat, Bovine, Human, Mouse, Chicken |
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Expression system |
HEK293 cells |
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Amino acid sequence |
QHYLHIRPAP SDNLPLVDLI EHPDPIFDPK EKDLNETLLR SLLGGHYDPG FMATSPPEDR PGGGGGAAGG AEDLAELDQL LRQRPSGAMP SEIKGLEFSE GLAQGKKQRL SKKLRRKLQM WLWSQTFCPV LYAWNDLGSR FWPRYVKVGS CFSKRSCSVP EGMVCKPSKS VHLTVLRWRC QRRGGQRCGW IPIQYPIISE CKCSC |
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Molecular weight |
46 kDa |
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Class |
Recombinant |
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Type |
Protein |
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Purity |
95% by SDS-PAGE gel and HPLC analyses. |
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Endotoxin concentration |
<1 EU/µg |
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Activity |
Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 2.0-3.0 ng/ml of Noggin. |
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Conjugate |
Unconjugated |
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Form |
Lyophilized |
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Purification |
purified |
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Contains |
no preservative |
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Storage conditions |
-20°C |
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Applications |
Tested Dilution |
Publications |
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Immunohistochemistry (IHC) |
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1 Publication |
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Flow Cytometry (Flow) |
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1 Publication |
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Functional Assay (Functional) |
Assay-dependent |
1 Publication |
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Inhibition Assays (IA) |
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1 Publication |
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In vitro Assay (IV) |
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140 Publications |
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Miscellaneous PubMed (Misc) |
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33 Publications |
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Product Specific Information
120-10C-1MG will be provided as 2 x 500 µg (120-10C-500UG).
Recombinant Human Noggin is a 46 kDa disulfide-linked homodimer consisting of two 205 amino acid polypeptide chains. Monomeric glycosylated noggin migrates at an apparent molecular weight of approximately 28.0-33.0 kDa by SDS PAGE analysis under reducing conditions.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot- specific Certificate of Analysis
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文献和实验[1]Ekanger CT, Zhou F, Bohan D, Lotsberg ML, Ramnefjell M, Hoareau L, Røsland GV, Lu N, Aanerud M, Gärtner F, Salminen PR, Bentsen M, Halvorsen T, Ræder H, Akslen LA, Langeland N, Cox R, Maury W, Stuhr LEB, Lorens JB, Engelsen AST. Human Organotypic Airway and Lung Organoid Cells of Bronchiolar and Alveolar Differentiation Are Permissive to Infection by Influenza and SARS-CoV-2 Respiratory Virus. Front Cell Infect Microbiol. 2022 Mar 14;12:841447. doi: 10.3389/fcimb.2022.841447. PMID: 35360113; PMCID: PMC8964279.
[2]Fumagalli A, Oost KC, Kester L, Morgner J, Bornes L, Bruens L, Spaargaren L, Azkanaz M, Schelfhorst T, Beerling E, Heinz MC, Postrach D, Seinstra D, Sieuwerts AM, Martens JWM, van der Elst S, van Baalen M, Bhowmick D, Vrisekoop N, Ellenbroek SIJ, Suijkerbuijk SJE, Snippert HJ, van Rheenen J. Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer. Cell Stem Cell. 2020 Apr 2;26(4):569-578.e7. doi: 10.1016/j.stem.2020.02.008. Epub 2020 Mar 12. PMID: 32169167; PMCID: PMC7118369.
[3]Liu F, Lin Q, Shen S, Li Z, Xie X, Cheng Q, Wang L, Long Y, Wang J, Liu L. Secretion of WNT7A by UC-MSCs assist in promoting the endometrial epithelial regeneration. iScience. 2024 May 3;27(6):109888. doi: 10.1016/j.isci.2024.109888. PMID: 38947517; PMCID: PMC11214297.
[4]Pereira VM, Pinto PAF, Motta LCB, Almeida MF, de Andrade AFC, Pavaneli APP, Ambrósio CE. Initial Characterization of 3D Culture of Yolk Sac Tissue. Animals (Basel). 2023 Apr 22;13(9):1435. doi: 10.3390/ani13091435. PMID: 37174472; PMCID: PMC10177165.
[5]Yao L, Lu F, Koc S, Zheng Z, Wang B, Zhang S, Skutella T, Lu G. LRRK2 Gly2019Ser Mutation Promotes ER Stress via Interacting with THBS1/TGF-β1 in Parkinson's Disease. Adv Sci (Weinh). 2023 Oct;10(30):e2303711. doi: 10.1002/advs.202303711. Epub 2023 Sep 6. PMID: 37672887; PMCID: PMC10602550.
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