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- 文献和实验
- 技术资料
- 库存：
大量
- 供应商：
PeproTech(派普泰克)
- 英文名：
Human FGF-basic (154 a.a.)
- 规格：
100ug
现货供应
产品描述：
FGF-basic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-basic is a non-glycosylated, heparin-binding growth factor that is expressed in the brain, pituitary, kidney, retina, bone, testis, adrenal gland, liver, monocytes, epithelial cells and endothelial cells. FGF-basic signals through FGFR 1b, 1c, 2c, 3c and 4. Recombinant Human FGF-basic is a 17.2 kDa protein consisting of 154 amino acid residues.
Qualified for stem cell use.
Source:E.coli
Synonyms:Fibroblast Growth Factor-basic, FGF-2, HBGF-2, Prostatropin
AA Sequence:AAGSITTLPA LPEDGGSGAF PPGHFKDPKR LYCKNGGFFL RIHPDGRVDG VREKSDPHIK LQLQAEERGV VSIKGVCANR YLAMKEDGRL LASKCVTDEC FFFERLESNN YNTYRSRKYT SWYVALKRTG QYKLGSKTGP GQKAILFLPM SAKS
Purity:≥ 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity:Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
This product has been tested against the WHO standard. International Unit information can be found
Calculated Molecular Weight:17.2 kDa
Accession Number:P09038
Gene ID:2247
Endotoxin:Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)
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Product Details |
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Size |
100 µg |
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Species |
Human |
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Expression system |
E. coli |
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Amino acid sequence |
AAGSITTLPA LPEDGGSGAF PPGHFKDPKR LYCKNGGFFL RIHPDGRVDG VREKSDPHIK LQLQAEERGV VSIKGVCANR YLAMKEDGRL LASKCVTDEC FFFERLESNN YNTYRSRKYT SWYVALKRTG QYKLGSKTGP GQKAILFLPM SAKS |
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Molecular weight |
17.2 kDa |
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Class |
Recombinant |
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Type |
Protein |
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Purity |
95% by SDS-PAGE gel and HPLC analyses. |
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Endotoxin concentration |
<1 EU/µg |
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Activity |
Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is 0.1 ng/ml, corresponding to a specific activity of 1 x 10^7 units/mg. |
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Conjugate |
Unconjugated |
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Form |
Lyophilized |
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Purification |
purified |
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Contains |
no preservative |
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Storage conditions |
-20°C |
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Applications |
Tested Dilution |
Publications |
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Western Blot (WB) |
Assay-dependent |
3 Publications |
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ELISA (ELISA) |
Assay-dependent |
2 Publications |
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Immunoprecipitation (IP) |
- |
1 Publication |
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Functional Assay (Functional) |
Assay-dependent |
- |
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Radioimmune Assays (RIA) |
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1 Publication |
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Control (Ctrl) |
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1 Publication |
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In vitro Assay (IV) |
- |
1419 Publications |
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Miscellaneous PubMed (Misc) |
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207 Publications |
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Immunostaining (IS) |
- |
1 Publication |
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Product Specific Information
Recombinant Human FGF-basic is a 17.2 kDa protein consisting of 154 amino acid residues. Qualified for stem cell use.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot- specific Certificate of Analysis
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文献和实验[1]Chu H, Gao J, Chen CW, Huard J, Wang Y. Injectable fibroblast growth factor-2 coacervate for persistent angiogenesis. Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13444-9. doi: 10.1073/pnas.1110121108. Epub 2011 Aug 1. PMID: 21808045; PMCID: PMC3158148.
[2]Nakayama T, Mutsuga N, Tosato G. FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc. Blood. 2007 Feb 15;109(4):1363-72. doi: 10.1182/blood-2006-06-028217. Epub 2006 Oct 31. PMID: 17077327; PMCID: PMC1794071.
[3]Hasson E, Gallula J, Shimoni Y, Grad-Itach E, Marikovsky M, Mitrani E. Skin-derived micro-organs induce angiogenesis in rabbits. J Vasc Res. 2006;43(2):139-48. doi: 10.1159/000090943. Epub 2006 Jan 11. PMID: 16407659.
[4]Kim HS, Yoon JW, Li H, Jeong GO, Park JJ, Shin SE, Jang IH, Kim JH, Park WS. Functional expression and pharmaceutical efficacy of cardiac-specific ion channels in human embryonic stem cell-derived cardiomyocytes. Sci Rep. 2017 Oct 23;7(1):13821. doi: 10.1038/s41598-017-14198-y. PMID: 29062050; PMCID: PMC5653792.
[5]Shi X, Jiang L, Zhao X, Chen B, Shi W, Cao Y, Chen Y, Li X, He Y, Li C, Liu X, Li X, Lu H, Chen C, Liu J. Adipose-Derived Stromal Cell-Sheets Sandwiched, Book-Shaped Acellular Dermal Matrix Capable of Sustained Release of Basic Fibroblast Growth Factor Promote Diabetic Wound Healing. Front Cell Dev Biol. 2021 Mar 25;9:646967. doi: 10.3389/fcell.2021.646967. PMID: 33842472; PMCID: PMC8027315.
[6]Arias AA, Neehus AL, Ogishi M, Meynier V, Krebs A, Lazarov T, Lee AM, Arango-Franco CA, Yang R, Orrego J, Corcini Berndt M, Rojas J, Li H, Rinchai D, Erazo-Borrás L, Han JE, Pillay B, Ponsin K, Chaldebas M, Philippot Q, Bohlen J, Rosain J, Le Voyer T, Janotte T, Amarajeeva K, Soudée C, Brollo M, Wiegmann K, Marquant Q, Seeleuthner Y, Lee D, Lainé C, Kloos D, Bailey R, Bastard P, Keating N, Rapaport F, Khan T, Moncada-Vélez M, Carmona MC, Obando C, Alvarez J, Cataño JC, Martínez-Rosado LL, Sanchez JP, Tejada-Giraldo M, L'Honneur AS, Agudelo ML, Perez-Zapata LJ, Arboleda DM, Alzate JF, Cabarcas F, Zuluaga A, Pelham SJ, Ensser A, Schmidt M, Velásquez-Lopera MM, Jouanguy E, Puel A, Krönke M, Ghirardello S, Borghesi A, Pahari S, Boisson B, Pittaluga S, Ma CS, Emile JF, Notarangelo LD, Tangye SG, Marr N, Lachmann N, Salvator H, Schlesinger LS, Zhang P, Glickman MS, Nathan CF, Geissmann F, Abel L, Franco JL, Bustamante J, Casanova JL, Boisson-Dupuis S. Tuberculosis in otherwise healthy adults with inherited TNF deficiency. Nature. 2024 Sep;633(8029):417-425. doi: 10.1038/s41586-024-07866-3. Epub 2024 Aug 28. PMID: 39198650; PMCID: PMC11390478.
[7]Chen C, Shu Y, Yan C, Li H, Huang Z, Shen S, Liu C, Jiang Y, Huang S, Wang Z, Mei F, Qin F, Liu X, Qiu W. Astrocyte-derived clusterin disrupts glial physiology to obstruct remyelination in mouse models of demyelinating diseases. Nat Commun. 2024 Sep 6;15(1):7791. doi: 10.1038/s41467-024-52142-7. PMID: 39242637; PMCID: PMC11379856.
[8]Linnerbauer M, Lößlein L, Vandrey O, Peter A, Han Y, Tsaktanis T, Wogram E, Needhamsen M, Kular L, Nagel L, Zissler J, Andert M, Meszaros L, Hanspach J, Zuber F, Naumann UJ, Diebold M, Wheeler MA, Beyer T, Nirschl L, Cirac A, Laun FB, Günther C, Winkler J, Bäuerle T, Jagodic M, Hemmer B, Prinz M, Quintana FJ, Rothhammer V. The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology. Nat Immunol. 2024 Mar;25(3):432-447. doi: 10.1038/s41590-024-01756-6. Epub 2024 Feb 26. PMID: 38409259; PMCID: PMC10907300.
[9]Xavier V, Martinelli S, Corbyn R, Pennie R, Rakovic K, Powley IR, Officer-Jones L, Ruscica V, Galloway A, Carlin LM, Cowling VH, Le Quesne J, Martinou JC, MacVicar T. Mitochondrial double-stranded RNA homeostasis depends on cell-cycle progression. Life Sci Alliance. 2024 Aug 29;7(11):e202402764. doi: 10.26508/lsa.202402764. PMID: 39209534; PMCID: PMC11361371.
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