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文献和实验Medications that have a narrow therapeutic window must be regularly monitored to assist in clinical dosing. Methotrexate (MTX) is one such chemotherapeutic agent that is closely monitored using various standard assays. Patients who have renal
Cytogenetic Characterization of Recombinant Cells
enables the cells to grow in a medium lacking the components glycine, hypoxanthine, and thymidine. Also, when multiple copies of the DHFR expression vector have been integrated, cellular resistance to methotrexate (MTX), a folate analog, is mediated. MTX
Structural Determinants of Folate and Antifolate Membrane Transport by the Reduced Folate Carrier
Besides its important role in folate homeostasis, membrane transport is a critical determinant of the antitumor activities of anti folate therapeutics used in cancer chemotherapy, such as methotrexate (MTX) and an exciting new generation
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