[26] Tsukaguchi K, Yoneda T, Okamura H, et al. DefectiveTcellfunctionforinhibitionofgrowthof Mycobacterium avium-intracellularecomplex (MAC) in patients with MACdisease:restoration and the origin of its altered function. In this review, we summarize these data and also discuss the role of aneuploidy as a negative regulator of local immunity.Cancer-associated fibroblasts (CAFs) are prominent cells within the tumor microenvironment, by communicating with other