LEP Polyclonal Antibody 货号：E-A

Verified Samples in IHC: Human colon, Human stomach, Mouse liver, Rat lung

IHC 1:100

Polyclonal

IgG

KLH conjugated Synthetic peptide corresponding to Mouse Leptin

LEP

FLJ94114, LEP, LEPD, Leptin, Leptin (murine obesity homolog), Leptin (obesity homolog, Leptin Murine Obesity Homolog, Leptin Precursor Obesity Factor, OB, Obese, Obese protein, Obesity, Obesity Murine H, Obesity factor, Obesity homolog mouse, homolog of, mouse, mouse)

P41159, P41160, P50596

Adipose tissue is the main source of leptin it is also produced by other peripheral tissues such as the skeletal muscle (PubMed:7789654, PubMed:16052473, PubMed:12448771). Expressed by intercalated and striated tracts of submandibular and parotid salivary gland intralobular ducts (PubMed:12448771). Detected by fundic epithelium of the gastric mucosa (PubMed:10896907). Secreted into blood and gastric juice (PubMed:10896907).

210 μg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH 7.4.

Affinity purification

Cancer, Cardiovascular, Metabolism, Neuroscience, Signal Transduction, Stem Cells

Unconjugated

This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.