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- Elabscience
- 湖北武汉
- E-AB-70311
- 2025年10月22日
- WB
- Rabbit
- Human;Mouse;Rat
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
IgG
- 形态：
液体
- 保存条件：
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
- 克隆性：
Polyclonal
- 标记物：
Unconjugated
- 适应物种：
Human;Mouse;Rat
- 保质期：
12个月
- 级别：
科研
- 库存：
999
- 供应商：
武汉伊莱瑞特生物科技股份有限公司
- 宿主：
Rabbit
- 应用范围：
WB
- 抗体英文名：
PD-1/CD279 Polyclonal Antibody
- 抗体名：
PD-1/CD279 Polyclonal Antibody_货号:E-AB-70311_多克隆抗体
- 规格：
200μL/120μL/60μL
| 规格： | 200μL | 产品价格： | ￥3300.0 |
|---|---|---|---|
| 规格： | 120μL | 产品价格： | ￥2220.0 |
| 规格： | 60μL | 产品价格： | ￥1380.0 |
PD-1/CD279 Polyclonal Antibody
| Verified Samples |
Verified Samples in WB: Human liver cancer, Mouse spleen, Mouse thymus, Mouse cecum, Mouse lymph nodes, Rat spleen, Rat thymus, Rat appendix, Rat lymph nodes
|
| Dilution |
WB 1:500-1:2000
|
| Clonality |
Polyclonal
|
| Isotype |
IgG
|
| Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse PD-1
|
| Abbre |
PD-1/CD279
|
| Synonyms |
CD279, CD279 antigen, PD 1, PD-1, PD1, PDCD 1, PDCD1, Programmed cell death 1, Programmed cell death 1 protein, Programmed cell death protein 1, Protein PD 1, Protein PD-1, SLEB2, Systemic lupus erythematosus susceptibility 2, hPD 1, hPD l, hPD-1, hSLE1
|
| Swissprot |
Q15116, Q02242
|
| Calculated MW |
32 kDa
|
| Observed MW |
47-55 kDa
|
| Cellular Localization |
Cell membrane, Membrane.
|
| Concentration |
0.75 mg/mL
|
| Storage |
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
|
| Buffer |
PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH 7.4.
|
| Purification Method |
Affinity purification
|
| Research Areas |
Cancer, Cell Biology, Immunology
|
| Conjugation |
Unconjugated
|
| Background |
Programmed cell death 1 (PD-1,also known as CD279) is an immunoinhibitory receptor that belongs to the CD28/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain,a stalk,a transmembrane domain,and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) . PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines . Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation,cytokine production,and cytolytic function . It is critical for the regulation of T cell function during immunity and tolerance. Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity . The calculated molecular weight of PD-1 is 32 kDa. It has been reported that PD-1 is heavily glycosylated and migrates with an apparent molecular mass of 47-55 kDa on SDS-PAGE .
|
PD-1/CD279 Polyclonal AntibodyElabscience®提供8000+经过实验验证的高品质一抗，主要包括： 流式抗体、 单抗、 多抗、 重组抗体、 内参/标签抗体、 乙酰化/磷酸化/甲基化抗体、 磁珠/凝胶偶连抗体、 病毒抗体等。
PD-1/CD279 Polyclonal AntibodyStore at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
PD-1/CD279 Polyclonal Antibody产品更多产品信息查看欢迎咨询我们和搜索武汉伊莱瑞特Elabscience官网查看。
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文献和实验Polyclonal Antibody Production
, if desired this is best accomplished by Protein A Affinity Chromatography. 上一篇：make an Antibody against a Peptides 下一篇：Immunization Protocol for Monoclonal Antibody Production
Construction of Polyclonal Antibody Libraries Using Phage Display
Polyclonal antibody libraries (PCALs) are standardized mixtures of antibodies (Abs) specific for an antigen (Ag) or multi-Ag target (a poly-Ag). As the immunoglobulin (Ig) genes are cloned, the mixtures can be perpetuated, amplified
Polyclonal Antibody Production
Polyclonal Antibody Production Very useful for rapid and simple generation of antibodies for western blots, ELISA assays, and immunoprecipitation. Rabbit Immunization Initial Preparation Your antigen
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