- ￥520 - 4038
- MedChemExpress(MCE)
- 美国
- HY-141487
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
312749-73-8
- 规格：
1 mg/5 mg/10 mg/25 mg
| 规格： | 1 mg | 产品价格： | ￥520.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1300.0 |
| 规格： | 10 mg | 产品价格： | ￥2145.0 |
| 规格： | 25 mg | 产品价格： | ￥4038.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
CLP-3094
CAS No. : 312749-73-8
MCE 国际站：CLP-3094
产品活性：CLP-3094 是一种有效的雄激素受体 (AR) BF3 (binding function 3) 抑制剂。BF3-IN-1 抑制 AR 转录活性 (IC50=4 μM)。CLP-3094 是一种选择性、有效的 GPR142 拮抗剂。
研究领域：Vitamin D Related/Nuclear Receptor
作用靶点：Androgen Receptor
In Vitro: CLP-3094 inhibits both an increase of intracellular Ca2+ concentration ([Ca2+]i) induced by L-tryptophan using CHO-K1 cells expressing GPR142 in the aequorin assay, and an accumulation of inositol phosphates using HEK293 cells expressing GPR142 in the SPA assay. The IC50 of CLP-3094 is 0.2 μM against 200 μM L-tryptophanfor the mouse receptor and 2.3 μM against 1 mM L-tryptophan for the human receptor in the aequorin assay. CLP-3094 also inhibits the insulin secretion from islets induced by both L-tryptophan and GPR142 agonists.
In Vivo: CLP-3094 (30, 100 mg/kg; i.p. daily from Day 0 to Day 11) consistently displayed sig-nificantly lower severity of arthritis scores than vehicletreated mice.
相关产品：Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Transcription Factor-Targeted Library | Anti-Prostate Cancer Compound Library | Nuclear Receptor Compound Library | Highly Selective Inhibitors Library | Enzalutamide | DHEA | Bavdegalutamide | Medroxyprogesterone acetate | Apalutamide | Darolutamide | Bicalutamide | Spironolactone | Flutamide | Danazol | Lupeol | ARCC-4 | 11-Ketodihydrotestosterone | Ailanthone | BMS-564929 | UT-34 | 3,3'-Diindolylmethane | VPC-14449 | PROTAC AR-V7 degrader-1 | AZD3514 | EPI-001 | Nilutamide | Ralaniten | Adrenocorticotropic hormone TFA | Drospirenone | Masofaniten | ARD-2585 | Dimethylcurcumin | Hydroxyflutamide
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验PCR仪美国伯乐DNA PCR仪 PTC-200/220/225原位全系列73新一代PCR仪Bio-RadC1000/S100074双色实时定量PCR仪Bio-RadDNA Engine Opticon 275多色实时定量PCR仪Bio-RadChromo476梯度PCR仪Bio-radMJ Mini77DNAEngine系列PCR仪Bio-Rad DNA Engine78定量PCR仪MJResearch Opticon279定量PCR仪MJResearch Opticon80原位PCR
GrailEXP and Genome Analysis Pipeline for Genome Annotation
. The SWISS‐PROT protein sequence data bank, recent developments. Nucl. Acids Res. 21:3093‐3094. Beck, S., Kelly, A., Radley, E., Khurshid, F., Alderton, R.P., and Trowsdale, J
l 6.82 µl 10% APS 76.4 µl 75 µl 73.6 µl 72.3 µl 70.9 µl 68.2 µl Heavy Acrylamide Gel Solutions for Standard Size Gradient Gels Acrylamide concentration of heavy gel solution (%) b Stock solution
技术资料暂无技术资料 索取技术资料
