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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
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MedChemExpress LLC
- CAS号：
211311-39-6
- 规格：
10 mM * 1 mL/1 mg/5 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1107.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥600.0 |
| 规格： | 5 mg | 产品价格： | ￥1500.0 |
| 规格： | 25 mg | 产品价格： | ￥4200.0 |
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AMPA receptor modulator-3
CAS No. : 211311-39-6
MCE 国际站：AMPA receptor modulator-3
产品活性：AMPA receptor modulator-3 是一种变构的 AMPA 受体调节剂 (EC50: 4.4 μM)。AMPA receptor modulator-3 可用于哺乳动物神经系统的研究，如学习和记忆能力。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点：iGluR
In Vitro: AMPA receptor modulator-3 (Compound 5e) shows an EC50 value of 4.4 μM for potentiation of responses mediated by 100 μM L-glutamate in HEK-293 cells expressing iGluR4 flip.
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文献和实验Monitoring Synaptic Plasticity by Imaging AMPA Receptor Content and Dynamics on Dendritic Spines
brain structures that are beyond the reach of traditional microscopes. Here, we describe an AMPA receptor-based optical approach to monitor recent history of synaptic plasticity. This method allows the identification of spines that have recently acquired
to LTD. These signaling molecules influence synaptic strength by modifying the phosphorylation state of many target proteins. In particular, bi-directional alterations in the phosphorylation of AMPA receptors can affect the trafficking and conductance of these receptors
Methods for Evaluation of Positive Allosteric Modulators of Glutamate AMPA Receptors
and are intimately involved in long-term changes in synaptic plasticity thought to underlie mnemonic processing. By definition, positive allosteric modulators do not affect AMPA receptor activity alone but can markedly enhance ion flux through the ion channel pore
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