Description :c-Rel is a member of the Rel/NF-κB transcription factor family that forms homo or heterodimerswith family members such as RelA/p65, RelB, NF-κB1/p105, and NF-κB2/p100. The NF-κBcomplex is retained in cytoplasm by the inhibitor IκB protein in unstimulated cells. Uponactivation, IκB is degraded via the ubiquitin-proteasome pathway, which results in nucleartranslocation of the active NF-κB complex. While other NF-κB transcription factors areexpressed in most cell types, relatively higher levels of c-REL expression are found inhematopoietic cells. c-REL is thought to play key roles in regulating proliferation,differentiation, and survival of B and T lymphocytes.
Verified Reactivity :Human
Antibody Type :Monoclonal
Host Species :Mouse
Immunogen :Partial c-REL recombinant protein (453-587 a.a.)
Formulation :This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation :Affinity purified
Concentration :0.5 mg/m
Storage & Handling :Upon receipt, store undiluted between 2°C and 8°C
Application :WB - Quality tested、ChIP - Verified
Recommended Usage :Each lot of this antibody is quality control tested by Western blotting. For Western blotting, thesuggested use of this reagent is 0.5 - 2.0 µg per ml. For ChIP applications, the suggested dilutionis 1:50-1:100 by volume. It is recommended that the reagent be titrated for optimal performance foreach application.