- ￥2500
- Vacara
- 10130
- 瑞典
- 2025年07月12日
- IHC, ELISA
- 小鼠
- Mouse, human
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
北京博蕾德生物科技有限公司
- 库存：
1
- 靶点：
Bovine Collagen type II
- 克隆性：
单克隆
- 抗原来源：
Bovine Collagen type II
- 保质期：
1年
- 抗体英文名：
Mouse Anti citrullinated COL2A1 Antibody (ACC1)
- 抗体名：
Mouse Anti citrullinated COL2A1 Antibody (ACC1)
- 标记物：
无
- 宿主：
小鼠
- 适应物种：
Mouse, human
- 免疫原：
Bovine Collagen type II
- 亚型：
Mouse IgG2a, κ
- 形态：
液体
- 应用范围：
IHC, ELISA
- 保存条件：
-20℃
- 浓度：
100µg / 0.1mL
- 规格：
100µg / 0.1mL
Description
Affinity purified mouse monoclonal anti collagen II (COL2A1) antibody clone ACC1 in PBS, sterile filtered (0.2 µm). The antibody binds to the citrullinated triple helical collagen type II (CII) epitope (position 359-369; ARGLTGRPGDA)1, the C1 epitope. The ACC1 antibody recognizes the second citrulline at position 365 in mouse CII1. The antibody binds to flexible triple-helical CII determinants as well as many citrullinated CII peptides and was found to cross-react with several non-citrullinated epitopes on native CII2. The antibody has been used in applications including ELISA1,2, immunohistochemistry (IHC)1 and bead-based multiplex immunoassays2.
Affinity purified mouse monoclonal anti collagen II (COL2A1) antibody clone ACC1 in PBS, sterile filtered (0.2 µm). The antibody binds to the citrullinated triple helical collagen type II (CII) epitope (position 359-369; ARGLTGRPGDA)1, the C1 epitope. The ACC1 antibody recognizes the second citrulline at position 365 in mouse CII1. The antibody binds to flexible triple-helical CII determinants as well as many citrullinated CII peptides and was found to cross-react with several non-citrullinated epitopes on native CII2. The antibody has been used in applications including ELISA1,2, immunohistochemistry (IHC)1 and bead-based multiplex immunoassays2.
Target with alternative names: COL2A1, Collagen alpha-1(II) chain, CII, Col II, citrullinated CII; citrullinated Col II; citrullinated proteins. UniProt: P28481.
Immunogen: Bovine Collagen type II 1
Species reactivity: Mouse, human
Isotype: Mouse IgG2a, κ
Specificity: ACC1 antibody binds the citrullinated C1 epitope. The ACC1 antibody cross-reacts with triple-helical epitopes on CII, but not with other collagens or the proteins tested in Ge et al2, except for a few citrullinated peptides.2
Concentration: 1 mg/ml
Supplied in: PBS
Storage: Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -‑20°C long term. Avoid repeated freeze/thaw cycles.
Recommended dilution: It is recommended the user determines the optimal dilution for their application. The typical starting working dilutions are: IHC 1:100, ELISA 1:200 - 1:500.
Immunogen: Bovine Collagen type II 1
Species reactivity: Mouse, human
Isotype: Mouse IgG2a, κ
Specificity: ACC1 antibody binds the citrullinated C1 epitope. The ACC1 antibody cross-reacts with triple-helical epitopes on CII, but not with other collagens or the proteins tested in Ge et al2, except for a few citrullinated peptides.2
Concentration: 1 mg/ml
Supplied in: PBS
Storage: Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -‑20°C long term. Avoid repeated freeze/thaw cycles.
Recommended dilution: It is recommended the user determines the optimal dilution for their application. The typical starting working dilutions are: IHC 1:100, ELISA 1:200 - 1:500.
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文献和实验该产品被引用文献
References
1. Uysal H, Bockermann R, Nandakumar KS, Sehnert B, Bajtner E, Engström A, Serre G, Burkhardt H, Thunnissen MM, Holmdahl R. Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis. J Exp Med. 2009 Feb 16;206(2):449-62. PMID: 19204106.
2. Ge C, Tong D, Liang B, Lönnblom E, Schneider N, Hagert C, Viljanen J, Ayoglu B, Stawikowska R, Nilsson P, Fields GB, Skogh T, Kastbom A, Kihlberg J, Burkhardt H, Holmdahl R. Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage. JCI Insight. 2017 Jul 6;2(13):e93688. PMID: 28679953.
1. Uysal H, Bockermann R, Nandakumar KS, Sehnert B, Bajtner E, Engström A, Serre G, Burkhardt H, Thunnissen MM, Holmdahl R. Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis. J Exp Med. 2009 Feb 16;206(2):449-62. PMID: 19204106.
2. Ge C, Tong D, Liang B, Lönnblom E, Schneider N, Hagert C, Viljanen J, Ayoglu B, Stawikowska R, Nilsson P, Fields GB, Skogh T, Kastbom A, Kihlberg J, Burkhardt H, Holmdahl R. Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage. JCI Insight. 2017 Jul 6;2(13):e93688. PMID: 28679953.
文献支持
Vacara cat#10130 Mouse Anti citrullinated COL2A1 Antibody (ACC1)
￥2500
