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- ProSci
- 美国
- PSI-80-036-0.1mg
- 2025年07月09日
- WB
- 兔
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Chk1 (phospho Ser286) antibody was raised against a peptide sequence around phosphorylation site of serine 286 (S-E-S (p)-P-S) derived from Human Chk1.
- 保存条件：
Store antibody at -20℃ for up to one year
- 保质期：
1年
- 级别：
科研级别
- 库存：
100
- 供应商：
艾美捷科技
- 宿主：
兔
- 应用范围：
WB
- 抗体英文名：
Chk1 (phospho Ser286) Antibody
- 抗体名：
Chk1 (phospho Ser286) Antibody
- 规格：
0.1mg
Chk1 (phospho Ser286) 抗体，Chk1 (phospho Ser286) Antibody，Chk1 (phospho Ser286) 抗体,Chk1 (phospho Ser286) Antibody
产品名称：Chk1 (phospho Ser286) 抗体-Chk1 (phospho Ser286) Antibody
产品货号：PSI-80-036-0.1mg
产品规格：0.1mg
背景资料：Required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A. Inhibition of CDC25 activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. Binds to and phosphorylates RAD51 at 'Thr-309', which may enhance the association of RAD51 with chromatin and promote DNA repair by homologous recombination. Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A. This may affect chromatin assembly during S phase or DNA repair. May also phosphorylate multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and enhances suppression of cellular proliferation.
保存建议：Chk1 (phospho Ser286) 抗体-Chk1 (phospho Ser286) AntibodyStore antibody at -20℃ for up to one year
应用类型：WB
点击：Chk1 (phospho Ser286) 抗体-Chk1 (phospho Ser286) Antibody查看更详细产品说明，更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看艾美捷特色产品中心。
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文献和实验Mammalian CHK1 is a Ser/Thr effector kinase that plays critical roles in the DNA damage-activated cell cycle checkpoint signaling pathway downstream of ATR (ATM and Rad3-related protein kinase). This chapter is focused on describing an assay
Methods for Studying Checkpoint Kinases Chk1
. Phospho-specific antibodies can be used to detect these activating phosphorylations, and this provides a simple and sensitive marker of Chk1 activation.
【求助】于NF-KB 激活，P65磷酸化位点是ser536还是ser276?
伽利略 ............................... chenlydd 两者都有,蛋白磷酸化水平与其功能密切相关：检测其磷酸化水平可用抗磷酸化位点抗体检测。www.cellsignal.com公司有相应抗体出售。 P65磷酸化位点: regulates apoptosis: S536‑p regulates cell growth: S536‑p regulates cell
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