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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Fusion protein from the C-terminus region of the NR2A subunit of rat NMDA receptor.
- 保存条件:
stored at -20℃ and is stable at -20℃ for at least 1 year
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
兔
- 应用范围:
WB
- 抗体英文名:
NMDA Antibody
- 抗体名:
NMDA Antibody
- 规格:
.05mL
NMDA 抗体,NMDA Antibody,NMDA 抗体,NMDA Antibody
产品名称:NMDA 抗体-NMDA Antibody
产品货号:PSI-50-180-.05mL
产品规格:.05mL
背景资料:The NMDA receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989; Alvestad et al., 2003; Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits.
保存建议:NMDA 抗体-NMDA Antibody stored at -20℃ and is stable at -20℃ for at least 1 year
应用类型:WB
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文献和实验Immunocytochemistry of NMDA Receptors
This chapter covers the major immunocytochemical methods used in our laboratory for NMDA receptor localization. There are three methods: pre-embedding immunoperoxidase for light microscopy (LM), the same for electron microscopy (EM
Redox Sensitivity of NMDA Receptors
The redox modulatory sites of the NMDA receptor consist of critical cysteine residues, which when chemically reduced, increase the magnitude of NMDA-evoked responses. In contrast, after oxidation, NMDA-evoked responses are decreased in size
Engineering the NMDA Receptor Channel Lining
Neurotransmitter-gated channels, such as the NMDA receptor, are oligomeric membrane proteins assembled from multiple homologous subunits organized around a central ion-conducting pore (1 ,2 ). A major effort is directed toward understanding
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