EGFR 抗体 [ERB7-1]-EGFR Antibody

EGFR 抗体 [ERB7-1]，EGFR Antibody [ERB7-1]，EGFR 抗体 [ERB7-1],EGFR Antibody [ERB7-1]

产品名称：EGFR 抗体 [ERB7-1]-EGFR Antibody [ERB7-1]

产品货号：PSI-33-875-100ug

产品规格：100ug

背景资料：Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. [UniProt]

保存建议：EGFR 抗体 [ERB7-1]-EGFR Antibody [ERB7-1]Aliquot and Store at 2-8℃

应用类型：IF, IHC-P

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