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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Recombinant human protein was used as the immunogen for this EGFR antibody.
- 保存条件:
Aliquot and Store at 2-8℃
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
小鼠
- 应用范围:
IHC, Flow, IF
- 抗体英文名:
EGFR Antibody [ERB59-1]
- 抗体名:
EGFR Antibody [ERB59-1]
- 规格:
100ug
EGFR 抗体 [ERB59-1],EGFR Antibody [ERB59-1],EGFR 抗体 [ERB59-1],EGFR Antibody [ERB59-1]
产品名称:EGFR 抗体 [ERB59-1]-EGFR Antibody [ERB59-1]
产品货号:PSI-33-893-100ug
产品规格:100ug
背景资料:Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. [UniProt]
保存建议:EGFR 抗体 [ERB59-1]-EGFR Antibody [ERB59-1]Aliquot and Store at 2-8℃
应用类型:IHC, Flow, IF
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文献和实验Anti-c-erb-B-2 Ribozyme for Breast Cancer
growth factor receptor (EGFR) (1 ,2 ) The putative ligand for c-erb -B-2 is thought to be gp30; however, its role in this process remains to be elucidated (3 ) Although EGFR can transform mouse NIH3T3 cells only in the presence of ligand and receptor
本文已发表于中国肿瘤生物治疗杂志.2003,10(3):221-222.【摘要】表皮生长因子受体(Epidermal Growth Factor Receptor EGFR)是原癌基因c-erb-B1的表达产物。其过表达和突变体均与肿瘤发生发展有密切关系,基于此优点成为目前肿瘤治疗的新靶点。本文就EGFR与肿瘤的关系及其单抗治疗肿瘤的进展作一综述。【关键词】表皮生长因子受体(EGFR),单克隆抗体,肿瘤治疗【中图分类号】R730.5 [文献标识码] AEGFR monocolonal
Radioimmunohistochemistry: Quantitative Analysis of Cell Surface Receptors in Frozen Sections
. The technique was pioneered in 1984 (1 ) for measurements of EGFR in squamous tumors and then modified (2 ) and applied to quantify the c-erb B-2 protein in breast carcinomas (3 ) using the ICR12 rat monoclonal antibody (4 ) (Dr. Chris Dean, Institute
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