PCNA 抗体 [PM441-1]-PCNA Antibod

PCNA 抗体 [PM441-1]，PCNA Antibody [PM441-1]，PCNA 抗体 [PM441-1],PCNA Antibody [PM441-1]

产品名称：PCNA 抗体 [PM441-1]-PCNA Antibody [PM441-1]

产品货号：PSI-33-862-100ug

产品规格：100ug

背景资料：Proliferating cell nuclear antigen is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion. [UniProt]

保存建议：PCNA 抗体 [PM441-1]-PCNA Antibody [PM441-1]Aliquot and Store at 2-8℃

应用类型：WB, IHC-P

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