E-Cadherin 抗体 [4A2]-E-Cadherin

E-Cadherin 抗体 [4A2]，E-Cadherin Antibody [4A2]，E-Cadherin 抗体 [4A2],E-Cadherin Antibody [4A2]

产品名称：E-Cadherin 抗体 [4A2]-E-Cadherin Antibody [4A2]

产品货号：PSI-33-607-100ug

产品规格：100ug

背景资料：Recognizes a protein of 80-120kDa, identified as E-cadherin/CDH1. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as b-catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma.

保存建议：E-Cadherin 抗体 [4A2]-E-Cadherin Antibody [4A2]Aliquot and Store at 2-8℃

应用类型：Flow, IF, WB, IHC-P

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