GOLPH1 抗体-GOLPH1 Antibody

GOLPH1 抗体，GOLPH1 Antibody，GOLPH1 抗体,GOLPH1 Antibody

产品名称：GOLPH1 抗体-GOLPH1 Antibody

产品货号：PSI-5439-0.02mg

产品规格：0.02mg

背景资料：GOLPH1 Antibody: GOLPH1, also known as GCP60, was initially identified as a Golgi protein that can interact with the integral membrane protein giantin and is thought to be involved in the maintenance of the Golgi structure. GOLPH1 has also been shown to interact with other Golgi proteins such as Golgin-160, a Golgi protein that can be cleaved by caspases-2, -3, and -7, leading to the nuclear localization of Golgin-160. GOLPH1 interaction with the Golgin-160 fragments is stronger than that with the intact Golgin-160, with its interaction regulated by the oxidation state of Cys-463 within GOLPH1, suggesting that the nuclear localization of the caspase-cleaved Golgin-160 fragments is a highly coordinated event. GOLPH1 has also been found to interact with Numb, a cytosolic signaling protein that mediates asymetric cell division of neural progenitor cells to a daughter progenitor cell and a neuron, suggesting that Golgi fragmentation and reconstitution during the cell cycle differentially regulate Numb signaling through changes in GOLPH1 subcellular distribution and may couple cell fate with cell cycle progression.

保存建议：GOLPH1 抗体-GOLPH1 Antibody stored at 4℃ for three months and -20℃, stable for up to one year

应用类型：E, WB

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