Description :CD61 is a 110 kD integrin β chain also known as β integrin or gpIIIa. It associates with theintegrin α chain (CD51) to form the vitronectin receptor. In addition, CD61 can associate withthe integrin α chain (CD41) to form the gpIIb/IIIa complex. CD61 is expressed on platelets,megakaryocytes, endothelium, smooth muscle, a subset of B cells, myeloid cells, osteoclasts,and mast cells. CD61, in conjunction with CD41 or CD51, mediates adhesion to fibronectin,fibrinogen, vitronectin, thrombospondin, and von Willebrand factor. Leukocyte-endothelialadhesion is mediated by the binding of α /β integrin or vitronectin receptor to CD31 (PECAM1).
Verified Reactivity :Mouse, Rat
Antibody Type :Monoclonal
Host Species :Armenian Hamster
Immunogen :Vitronectin receptor protein from the mouse T-cell hybridoma 2B4.
Preparation :The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 underoptimal conditions.
Concentration :0.2 mg/ml
Storage & Handling :The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application :FC - Quality tested
Recommended Usage :Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is =0.25 µg per million cellsin 100 µl volume. It is recommended that the reagent be titrated for optimal performance for eachapplication.