Description :Ikaros, also known as IKZF1, belongs to a family of zinc-finger DNA-binding proteins thatregulate lymphocyte differentiation. It has the ability to form homo- and heterodimers with othermembers of the Ikaros family, which include Aiolos and Helios. Ikaros can be found on amajority of fetal and adult hematopoietic cell types such as T- and B-cells, natural killer cells(NKs), monocytes/macrophages, and dendritic cells. Ikaros is a tumor suppressor and itsabsence or reduced expression has been reported in several leukemias.
Preparation :The antibody was purified by affinity chromatography.
Concentration :0.5 mg/mL
Storage & Handling :The antibody solution should be stored undiluted between 2°C and 8°C.
Application :WB - Quality tested、ChIP - Verified
Recommended Usage :Each lot of this antibody is quality control tested by Western blotting. For Western blotting, thesuggested use of this reagent is 0.5 - 2.0 µg per mL. The recommended starting antibody tochromatin ratio is 4 µg of antibody and 5 µg of chromatin per IP. Optimal antibody to chromatinratio should be determined by the end user. It is recommended that the reagent be titrated foroptimal performance for each application.