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- 齐源
- 323502
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- 2025年07月15日
- FC, ICC
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
CD140a
- 级别：
CD140a (PDGFRα) Antibody
- 目录编号：
CD140a (PDGFRα) Antibody
- 克隆性：
单克隆
- 抗原来源：
小鼠
- 保质期：
CD140a (PDGFRα) Antibody
- 抗体英文名：
Purified anti-human CD140a (PDGFRα) Antibody
- 抗体名：
CD140a (PDGFRα) Antibody
- 标记物：
CD140a (PDGFRα) Antibody
- 宿主：
小鼠
- 适应物种：
人
- 免疫原：
CD140a (PDGFRα) Antibody
- 亚型：
CD140a (PDGFRα) Antibody
- 形态：
CD140a (PDGFRα) Antibody
- 应用范围：
FC, ICC
- 保存条件：
2-8℃
- 浓度：
0.5 mg/mL
- 规格：
100 µg
Purified anti-human CD140a (PDGFRα) Antibody详细如下：
Description ：The 16A1 monoclonal antibody recognizes human CD140a also known as the platelet-derivedgrowth factor receptor, alpha polypeptide, PDGFR2, and PDGFRα. CD140a is a cell surfacetyrosine kinase receptor for members of the platelet-derived growth factor family. The identityof the growth factor bound to the receptor determines whether the functional receptor is ahomodimer or heterodimer composed of both PDGFR-α and -β. CD140a contains threeimmunoglobulin-like domains and a tyrosine kinase domain with a predicted molecular weight ofapproximately 123 kD. CD140a is widely expressed on a variety of mesenchymal-derived cellsand has been implicated in the development of some tumors including basal cell carcinomaand gastric stromal cell tumors. Binding of A-chain containing PDGF molecules as well asprotease-activated PDGF-C molecules can stimulate cell proliferation. CD140a has beenshown to interact with a number of proteins including CRK, Grb2, Grb14, SHP2, and others asintegrin β3, caveolin-1, and nexin sorting molecules. The PDGFRα is heavily phosphorylatedon numerous tyrosine residues through both autophosphorylation and ligand-dependentprocesses. The 16A1 antibody has been shown to be useful for flow cytometric detection ofCD140a.
Verified Reactivity ：Human
Antibody Type ：Monoclonal
Host Species ：Mouse
Immunogen ：NIH 3T3 cells transfected with human PDGFRalpha
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography
Concentration ：0.5 mg/mL
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C.
Application ：FC - Quality tested、ICC - Reported in the literature, not verified in house
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per 106 cells in100 µL volume. It is recommended that the reagent be titrated for optimal performance for eachapplication.
Description ：The 16A1 monoclonal antibody recognizes human CD140a also known as the platelet-derivedgrowth factor receptor, alpha polypeptide, PDGFR2, and PDGFRα. CD140a is a cell surfacetyrosine kinase receptor for members of the platelet-derived growth factor family. The identityof the growth factor bound to the receptor determines whether the functional receptor is ahomodimer or heterodimer composed of both PDGFR-α and -β. CD140a contains threeimmunoglobulin-like domains and a tyrosine kinase domain with a predicted molecular weight ofapproximately 123 kD. CD140a is widely expressed on a variety of mesenchymal-derived cellsand has been implicated in the development of some tumors including basal cell carcinomaand gastric stromal cell tumors. Binding of A-chain containing PDGF molecules as well asprotease-activated PDGF-C molecules can stimulate cell proliferation. CD140a has beenshown to interact with a number of proteins including CRK, Grb2, Grb14, SHP2, and others asintegrin β3, caveolin-1, and nexin sorting molecules. The PDGFRα is heavily phosphorylatedon numerous tyrosine residues through both autophosphorylation and ligand-dependentprocesses. The 16A1 antibody has been shown to be useful for flow cytometric detection ofCD140a.
Verified Reactivity ：Human
Antibody Type ：Monoclonal
Host Species ：Mouse
Immunogen ：NIH 3T3 cells transfected with human PDGFRalpha
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography
Concentration ：0.5 mg/mL
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C.
Application ：FC - Quality tested、ICC - Reported in the literature, not verified in house
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per 106 cells in100 µL volume. It is recommended that the reagent be titrated for optimal performance for eachapplication.
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文献和实验该产品被引用文献
Application References(PubMed link indicatesBioLegend citation)：
1. Miyazaki S et al. In:Leukocyte Typing VI Kishimoto et al. Eds, Garland Publishing Inc, New York1998 pp 3-20.
2. Lottaz C, et al. 2010. Cancer Res. 70:2030. PubMed
3. Ricono JM, et al. 2009. Am. J. Physiol. Renal Physiol. 296:F406. (IF)
4. Guarnerio J, et al. 2015. Cancer Discov. 5:396. PubMed
Product Citations：
1. Leelatian N, et al. 2020. eLife. 9:e56879.. PubMed
1. Miyazaki S et al. In:Leukocyte Typing VI Kishimoto et al. Eds, Garland Publishing Inc, New York1998 pp 3-20.
2. Lottaz C, et al. 2010. Cancer Res. 70:2030. PubMed
3. Ricono JM, et al. 2009. Am. J. Physiol. Renal Physiol. 296:F406. (IF)
4. Guarnerio J, et al. 2015. Cancer Discov. 5:396. PubMed
Product Citations：
1. Leelatian N, et al. 2020. eLife. 9:e56879.. PubMed
文献支持
Purified 抗人 CD140a (PDGFRα) 抗体
￥2000
