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- 齐源
- 355601
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- 2025年07月12日
- FC, ICC
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
CD227
- 级别：
CD227 (MUC-1) Antibody
- 目录编号：
CD227 (MUC-1) Antibody
- 克隆性：
单克隆
- 抗原来源：
小鼠
- 保质期：
CD227 (MUC-1) Antibody
- 抗体英文名：
Purified anti-human CD227 (MUC-1) Antibody
- 抗体名：
CD227 (MUC-1) Antibody
- 标记物：
CD227 (MUC-1) Antibody
- 宿主：
小鼠
- 适应物种：
人
- 免疫原：
CD227 (MUC-1) Antibody
- 亚型：
CD227 (MUC-1) Antibody
- 形态：
CD227 (MUC-1) Antibody
- 应用范围：
FC, ICC
- 保存条件：
2-8℃
- 浓度：
0.5 mg/mL
- 规格：
25 µg/100 µg
| 规格： | 25 µg | 产品价格： | ￥1300.0 |
|---|---|---|---|
| 规格： | 100 µg | 产品价格： | ￥2400.0 |
Purified anti-human CD227 (MUC-1) Antibody详细如下：
Description ：Mucin-1 (MUC-1), cell surface associated or polymorphic epithelia mucin, is a 500-1000 kDproteoglycan expressed by activated T cells, mucosal epithelial cells, and aberrantly expressedon most breast cancers. In normal cells, CD227 is heavily glycosylated, whereas in cancerouscells, the glycosylation is incomplete and premature sialation is also observed. The protein isanchored to the a-pical surface of the epithelial cell and functions as a lubricant to keep the cellhydrated and to protect against pathogens. It can also function as a signaling molecule byforming a MUC-1/SOS1/GrB2 complex. MUC-1 can interact with cancer antigens such asHer2/neu.
Verified Reactivity ：Human
Antibody Type ：Monoclonal
Host Species ：Mouse
Immunogen ：Jurkat cells transfected with MUC1
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography.
Concentration ：0.5 mg/mL
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C
Application ：FC - Quality tested、ICC, IHC-P - Verified
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cellsin 100 µL volume. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections,a concentration range of 1 - 10 µg/mL is suggested. It is recommended that the reagent be titratedfor optimal performance for each application.
Description ：Mucin-1 (MUC-1), cell surface associated or polymorphic epithelia mucin, is a 500-1000 kDproteoglycan expressed by activated T cells, mucosal epithelial cells, and aberrantly expressedon most breast cancers. In normal cells, CD227 is heavily glycosylated, whereas in cancerouscells, the glycosylation is incomplete and premature sialation is also observed. The protein isanchored to the a-pical surface of the epithelial cell and functions as a lubricant to keep the cellhydrated and to protect against pathogens. It can also function as a signaling molecule byforming a MUC-1/SOS1/GrB2 complex. MUC-1 can interact with cancer antigens such asHer2/neu.
Verified Reactivity ：Human
Antibody Type ：Monoclonal
Host Species ：Mouse
Immunogen ：Jurkat cells transfected with MUC1
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography.
Concentration ：0.5 mg/mL
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C
Application ：FC - Quality tested、ICC, IHC-P - Verified
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cellsin 100 µL volume. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections,a concentration range of 1 - 10 µg/mL is suggested. It is recommended that the reagent be titratedfor optimal performance for each application.
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文献和实验该产品被引用文献
Application References(PubMed link indicatesBioLegend citation)：
1. Song W, et al. 2012. Int. J Oncol. 41:1977. PubMed
Product Citations：
1. Hinohara K, et al. 2018. Cancer Cell. 34:939. PubMed
2. Murad JP, et al. 2018. Front Immunol. 1.95. PubMed
3. Huerta–Nuñ ez LFE, et al. 2019. Sci Rep. 9:6419. PubMed
4. Ding L, et al. 2019. Nat Commun. 10:4182. PubMed
1. Song W, et al. 2012. Int. J Oncol. 41:1977. PubMed
Product Citations：
1. Hinohara K, et al. 2018. Cancer Cell. 34:939. PubMed
2. Murad JP, et al. 2018. Front Immunol. 1.95. PubMed
3. Huerta–Nuñ ez LFE, et al. 2019. Sci Rep. 9:6419. PubMed
4. Ding L, et al. 2019. Nat Commun. 10:4182. PubMed
文献支持
Purified 抗人 CD227 (MUC-1) 抗体
￥1300 - 2400
