Purified 抗人 CD369 (Dectin-1/CL

Purified anti-human CD369 (Dectin-1/CLEC7A) Antibody详细如下：

Description ：CD369 (Dectin-1), also known as CLEC7A and beta-glucan receptor (BGR), is a 33 kD type IItransmembrane C-type lectin. It consists of a C-terminal stalk with a carbohydrate recognitiondomain (CRD) in the extracellular domain, a transmembrane segment, and a short N-terminalITAM containing a cytoplasmic tail. CLEC7A is predominantly expressed on dendritic cells.Subsequent work has shown expression on B cells, monocytes, eosinophils, mast cells,macrophages, endothelial cells, and low expression on some subsets of T cells. CLEC7A lacksresidues involved in calcium ligation that mediates carbohydrate-binding by classical C-typelectins. CLEC7A functions as a receptor to mediate innate immunity to fungal pathogens byselectively binding beta-glucan polymers, a major component of yeast and mycobacterial cellwalls.

Verified Reactivity ：Human

Antibody Type ：Monoclonal

Host Species ：Mouse

Immunogen ：Ectodomain with C-term hFc fusion, RIBLS.

Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation ：The antibody was purified by affinity chromatography.

Concentration ：0.5 mg/ml

Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C.

Application ：FC - Quality tested、IHC-F - Reported in the literature, not verified in house

Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cellsin 100 µl volume. It is recommended that the reagent be titrated for optimal performance for eachapplication.