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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
齐源
- 库存:
999
- 靶点:
CD172a (SIRPα)
- 级别:
CD172a (SIRPα) Antibody
- 目录编号:
CD172a (SIRPα) Antibody
- 克隆性:
单克隆
- 抗原来源:
小鼠
- 保质期:
CD172a (SIRPα) Antibody
- 抗体英文名:
Purified anti-human CD172a (SIRPα) Antibody
- 抗体名:
CD172a (SIRPα) Antibody
- 标记物:
CD172a (SIRPα) Antibody
- 宿主:
小鼠
- 适应物种:
人
- 免疫原:
CD172a (SIRPα) Antibody
- 亚型:
CD172a (SIRPα) Antibody
- 形态:
CD172a (SIRPα) Antibody
- 应用范围:
FC
- 保存条件:
2-8℃
- 浓度:
0.5 mg/ml
- 规格:
100 µg
Description :CD172a, also known as signal-regulatory protein α (SIRPα), is a 85-90 kD, type Itransmembrane protein with one V-set Ig-like and two C-set Ig-like domains in the extracellularportion, and two ITIM motifs and a proline-rich region in the cytoplasmic tail. SIRPα is involvedin the negative regulation of receptor tyrosine kinase-coupled signaling; the phospho-tyrosineresidues of this protein recruit SH2 domain-containing tyrosine phosphatases (PTP), and serveas substrates of PTPs. CD172a is primarily expressed on monocytes/macrophages,granulocytes, dendritic cells, neurons and by cardiomyocytes derived from human pluripotentstem cells. The ligands of CD172a are CD47, SP-A, and SP-D.
Verified Reactivity :Human
Antibody Type :Monoclonal
Host Species :Mouse
Immunogen :KG1a cells.
Formulation :Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation :The antibody was purified by affinity chromatography.
Concentration :0.5 mg/ml
Storage & Handling :The antibody solution should be stored undiluted between 2°C and 8°C.
Application :FC - Quality tested
Recommended Usage :Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cellsin 100 µl volume. It is recommended that the reagent be titrated for optimal performance for eachapplication.
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文献和实验1. Majdic O, et al. 1981. Blood. 58:1127.
Product Citations:
1. Roussel M, et al. 2021. Cell Reports Medicine. 2(6):100291. PubMed
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