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- 2025年07月15日
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- 亚美尼亚仓鼠
- 小鼠
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
CD103
- 级别：
CD103 Antibody
- 目录编号：
CD103 Antibody
- 克隆性：
单克隆
- 抗原来源：
亚美尼亚仓鼠
- 保质期：
CD103 Antibody
- 抗体英文名：
Pacific Blue™ anti-mouse CD103 Antibody
- 抗体名：
CD103 Antibody
- 标记物：
CD103 Antibody
- 宿主：
亚美尼亚仓鼠
- 适应物种：
小鼠
- 免疫原：
CD103 Antibody
- 亚型：
CD103 Antibody
- 形态：
CD103 Antibody
- 应用范围：
FC
- 保存条件：
2-8℃
- 浓度：
0.5 mg/ml
- 规格：
25 µg/100 µg
| 规格： | 25 µg | 产品价格： | ￥2400.0 |
|---|---|---|---|
| 规格： | 100 µg | 产品价格： | ￥5000.0 |
Description ：CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin α chain. Itbelongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes(IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendriticcells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. Tregulatory cells express high level of CD103. The CD103 expression on lymphocytes can beinduced upon activation and TGF-β stimulation. In association with integrin β , CD103 isexpressed as αE/β heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds.CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.
Verified Reactivity ：Mouse
Antibody Type ：Monoclonal
Host Species ：Armenian Hamster
Immunogen ：Mouse intestinal intraepithelial lymphocytes
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography, and conjugated with Pacific Blue™ underoptimal conditions.
Concentration ：0.5 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application ：FC - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10 cells in100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimalperformance for each application.
* Pacific Blue™ has a maximum emission of 455 nm when it is excited at 405 nm. Prior to usingPacific Blue™ conjugate for flow cytometric analysis, please verify your flow cytometer's capabilityof exciting and detecting the fluorochrome.
Excitation Laser ：Violet Laser (405 nm)
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文献和实验1. LeFrancois L, et. al, 1994. Eur. J. Immunol. 24:635. (FC, IHC, IP)
2. Mysorekar IU, et. al, 2002. J. Biol. Chem. 277:37811. (FC, IF)
3. Mikami N, et al. 2011. J. Immunol. 186:6886. PubMed
4. del Rio ML, et al. 2011. Transpl. Int. 24:501. (FC) PubMed
5. Quinn KM, et al. 2013. J. Immunol. 191:5085. PubMed
6. Verhagen J and Wraith DC. 2014. J. Immunol. Methods. S0022. (FC) PubMed
7. Xiao B, et al. 2015. PLoS One 1:e0115333. (IHC)
Product Citations：
1. Dudek M, et al. 2015. Mucosal Immunol. . PubMed
2. Christian LS, et al. 2021. Cell Reports. 35(6):109118. PubMed
3. Domingos-Pereira S, et al. 2019. Cancer Immunol Res. 7:621. PubMed
4. Dietmar Herndler‐Brandstetter et al. 2018. Immunity. 48(4):716-729 . PubMed
5. Gomez S, et al. 2022. J Immunother Cancer. 10:. PubMed
6. Pai M, et al. 2016. JPEN J Parenter Enteral Nutr. 40: 383 - 391. PubMed
7. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
8. Ramanan D, et al. 2020. Cell. 181(6):1276-1290. PubMed
9. Bosteels C, et al. 2020. Immunity. 52(6):1039-1056.e9.. PubMed
10. Malenica I, et al. 2021. Nat Commun. 12:5209. PubMed
11. Wang Y, et al. 2022. Nat Cell Biol. 24:230. PubMed
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