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- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
SOX2
- 级别：
SOX2 Antibody
- 目录编号：
SOX2 Antibody
- 克隆性：
单克隆
- 抗原来源：
小鼠
- 保质期：
SOX2 Antibody
- 抗体英文名：
Brilliant Violet 421™ anti-SOX2 Antibody
- 抗体名：
SOX2 Antibody
- 标记物：
SOX2 Antibody
- 宿主：
小鼠
- 适应物种：
人、小鼠
- 免疫原：
SOX2 Antibody
- 亚型：
SOX2 Antibody
- 形态：
SOX2 Antibody
- 应用范围：
ICC
- 保存条件：
2-8℃
- 浓度：
0.2 mg/ml
- 规格：
100 µg
Description ：SOX2 is the most studied member of SRY-related box transcription factor family. It binds totarget genes through its highly conserved HMG box domain. Inactivation of the SOX2 genecauses lethality during embryonic development. SOX2 knockdown in embryonic stem cellsresults in their differentiation. Co-expression of SOXwith OCT4, MYC, and KLF4 is sufficient toreprogram somatic cells to induced pluripotent stem cells (iPSCs), which exert similarcharacteristics as natural pluripotent stem cells. These findings indicate that SOX2 is crucial forthe self-renewal and pluripotency of embryonic stem cells. In addition, over-expression of SOX2has been found in various types of malignant cancer. Knockdown of SOX2 results in cell cyclearrest by downregulating cyclin D1 and inhibition of tumor cell proliferation, suggesting thatSOX2 is involved in activating genes associated with tumor progression.
Verified Reactivity ：Human, Mouse
Antibody Type ：Monoclonal
Host Species ：Mouse
Immunogen ：Full length human SOX recombinant protein
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
Preparation ：The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421™under optimal conditions.
Concentration ：0.2 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application ：ICC - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by immunocytochemistry. Forimmunocytochemistry, a concentration range of 0.1 - 10 μg/ml is recommended. It is recommendedthat the reagent be titrated for optimal performance for each application.
Brilliant Violet 421™ excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50nm is recommended for detection. Brilliant Violet 421™ is a trademark of Sirigen Group Ltd.
Excitation Laser ：Violet Laser (405 nm)
Application Notes ：This clone is not recommended for ChIP (Chromatin Immunoprecipitation) assays (as determinedby in-house testing).
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文献和实验1. Yamasaki S, et al. 2022. iScience. 25:103657. PubMed
2. Matsuda M, et al. 2020. Nature. 124:580. PubMed
3. Shiba T, et al. 2019. J Allergy Clin Immunol. 144:1438. PubMed
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以上的大分子染料（BV /BUV/Super bright），配制染色抗体混合液时，建议使用BV staining Buffer （货号： 00-4409-75）或Super Bright Complete Staining Buffer（货号：SB-4401-42）添加在染色体系中。 Super Bright Complete Staining Buffer, eBioscience：单个样品加 5 μL Brilliant Stain Buffer：单个样品加 50 μL
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Violet 421 标记抗小鼠MHC II（I-A/I-E）抗体[M5/114] AN00821Q2 Elab Bright™ Violet 421 标记大鼠IgG2b，κ同型对照抗体[R35-38] E-AB-F1136S Elab Fluor® Red 780 标记抗小鼠CD45抗体[30-F11] E-AB-F1081T Elab Fluor® Violet 610 标记抗小鼠/人/猴CD11b抗体[M1/70] E-AB-F1186C FITC 标记抗小鼠CD64/FcγRI抗体
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