- ￥1700 - 5100
- 齐源
- 662801
- 国产/进口
- 2025年07月12日
- WB
- 大鼠
- 小鼠
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
Granzyme B
- 级别：
Granzyme B Antibody
- 目录编号：
Granzyme B Antibody
- 克隆性：
单克隆
- 抗原来源：
大鼠
- 保质期：
Granzyme B Antibody
- 抗体英文名：
Purified anti-Granzyme B Antibody
- 抗体名：
Granzyme B Antibody
- 标记物：
Granzyme B Antibody
- 宿主：
大鼠
- 适应物种：
小鼠
- 免疫原：
Granzyme B Antibody
- 亚型：
Granzyme B Antibody
- 形态：
Granzyme B Antibody
- 应用范围：
WB
- 保存条件：
2-8℃
- 浓度：
0.5 mg/ml
- 规格：
25 µg/100 µg
| 规格： | 25 µg | 产品价格： | ￥1700.0 |
|---|---|---|---|
| 规格： | 100 µg | 产品价格： | ￥5100.0 |
Description ：Granzyme B is a serine protease expressed by cytotoxic T cells (CTL) and NK cells. Its mainfunction is to induce cell death to eliminate harmful targets such as allogeneic, virally infected,and tumor cells. This is evident by the fact that CTLs from mice deficient of granzyme B exhibita profound defect in inducing rapid DNA fragmentation and apoptosis in target cells. Followingreceptor-mediated conjugate formation between CTL or NK and their target cell, granzyme Benters the target via endocytosis, and subsequently activates multiple protein substrates toinduce apoptosis. Most circulating CD56 and CD8 NK cells, and approximately half ofcirculating CD8 T cells, coexpress both granzyme A and B. In contrast, few circulating CD4 Tcells express granzymes A or B. Activation of CD8 and CD4 T cells induces substantialexpression of granzyme B, but not granzyme A. Besides CTL and NK, evidence has shown thatthe distribution of human granzyme B has a broader spectrum of cells including CD34hematopoietic progenitor cells, keratinocytes, basophils, mast cells, plasmacytoid dendriticcells, and B cells. Although its role in cytotoxic lymphocyte-mediated apoptosis is wellestablished, granzyme B can also degrade extracellular matrix proteins and alter inflammation,if present in the extracellular milieu. These findings suggest that granzyme B can function asan activation molecule with potentially important immunoregulatory functions. In addition, it wasshown that expression of granzyme B is elevated in acute coronary syndrome and acutemyocardial infarction, indicating that granzyme B could be a factor involved in cardiovasculardiseases.
Verified Reactivity ：Mouse
Antibody Type ：Monoclonal
Host Species ：Rat
Immunogen ：Partial mouse Granzyme B recombinant protein (17-247 aa) expressed in E. coli.
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography.
Concentration ：0.5 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C.
Application ：WB - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by Western blotting. For Western blotting, thesuggested use of this reagent is 0.1 - 0.5 µg per ml. It is recommended that the reagent be titratedfor optimal performance for each application.
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验1. Anthony SM, et al. 2021. eLife. 10:00. PubMed
IgG抗A（抗B）测定 （一）原理 血清以巯基乙醇（2－erptethn，简称2－e）处理后，IgM抗体分子裂解为6～7S亚单位。此种亚单位虽然仍保持与抗原结合的能力，但已失去其与相应红细胞凝集的作用。IgG抗体分子则不被2－e灭活，保持与相应红细胞致敏的血清学特性。IgA抗体分子可部分被灭活（7S单体不受影响，9S及11S多聚体被灭活）。 （二）试剂和材料 1．0．2／L2－巯基乙醇应用液取巯基乙醇1．6，以pH7．4的PBS（KH2PO41．73g，N2HPO
人抗狂犬病毒抗体(anti-RV)酶联免疫分析（ELISA）
人抗狂犬病毒抗体 (anti-RV) 酶联免疫分析（ ELISA ） 试剂盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定人血清，血浆及相关液体样本中抗狂犬病毒抗体(anti-RV) 的含量。 实验原理： 本试剂盒应用双抗体夹心法测定标本中 人抗狂犬病毒抗体 (anti-RV) 水平。用纯化的 人狂犬病毒抗体 包被微孔板，制成固相抗体，往包被单抗的微孔中依次加入 犬狂犬病毒抗体
人抗环瓜氨酸肽抗体（CCP ） 酶联免疫分析（ ELISA ） 试剂盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定人血清，血浆及相关液体样本中抗环瓜氨酸肽抗体（CCP ）含量。 实验原理： 本试剂盒应用双抗原夹心法测定标本中人抗环瓜氨酸肽抗体（ CCP ）水平。用纯化的抗原包被微孔板，制成固相抗原，往包被单抗的微孔中依次加入抗环瓜氨酸肽抗体（ CCP ），再与 HRP 标记的抗原
