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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
齐源
- 库存:
999
- 靶点:
Th-POK
- 级别:
Th-POK (ZFP-67) Antibody
- 目录编号:
Th-POK (ZFP-67) Antibody
- 克隆性:
单克隆
- 抗原来源:
小鼠
- 保质期:
Th-POK (ZFP-67) Antibody
- 抗体英文名:
anti-Th-POK (ZFP-67) Antibody-APC
- 抗体名:
Th-POK (ZFP-67) Antibody
- 标记物:
APC
- 宿主:
小鼠
- 适应物种:
人
- 免疫原:
Th-POK (ZFP-67) Antibody
- 亚型:
Th-POK (ZFP-67) Antibody
- 形态:
Th-POK (ZFP-67) Antibody
- 应用范围:
ICFC
- 保存条件:
2-8℃
- 浓度:
Th-POK (ZFP-67) Antibody
- 规格:
25 tests/100 tests
| 规格: | 25 tests | 产品价格: | ¥2700.0 |
|---|---|---|---|
| 规格: | 100 tests | 产品价格: | ¥6300.0 |
Description :Th-POK is a member of the BTB-POZ domain-containing zinc finger transcription factor family.It regulates gene expression during intrathymic T cell differentiation. A single autosomalrecessive mutation of the Th-POK gene results in the absence of mature CD4+ helper T cells,called helper-deficient (HD) phenotype. In Th-POK deficient mice, MHC class II restrictedthymocytes are redirected to the CD8+ T cell lineage. On the contrary, forced expression ofTh-POK redirects MHC class I restricted thymocytes to the CD4+ T cell lineage. Inactivation ofTh-POK in mature CD4+ T cells results in induction of the genes preferentially expressed inCD8+ T cells, such as CD8, granzyme B, and IFN-γ. These findings suggest that Th-POK isessential in promoting commitment of immature T cells to the CD4 lineage and maintaining thecharacteristics of mature CD4+ T helper cells.
Verified Reactivity :Human
Antibody Type :Monoclonal
Host Species :Mouse
Immunogen :Partial human Th-POK recombinant protein (197-345 a.a.)
Formulation :Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation :The antibody was purified by affinity chromatography and conjugated with APC under optimalconditions.
Concentration :Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysis online tool.)
Storage & Handling :The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application :ICFC - Quality tested
Recommended Usage :Each lot of this antibody is quality control tested by intracellular immunofluorescent staining withflow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL permillion cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended thatthe reagent be titrated for optimal performance for each application.
Excitation Laser :Red Laser (633 nm)
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