- ￥4500
- 齐源
- 656402
- 国产/进口
- 2025年07月08日
- WB, ICC
- 小鼠
- 人
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- 详细信息
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
Th-POK
- 级别：
Th-POK (ZFP-67) Antibody
- 目录编号：
Th-POK (ZFP-67) Antibody
- 克隆性：
单克隆
- 抗原来源：
小鼠
- 保质期：
Th-POK (ZFP-67) Antibody
- 抗体英文名：
Purified anti-Th-POK (ZFP-67) Antibody
- 抗体名：
Th-POK (ZFP-67) Antibody
- 标记物：
Th-POK (ZFP-67) Antibody
- 宿主：
小鼠
- 适应物种：
人
- 免疫原：
Th-POK (ZFP-67) Antibody
- 亚型：
Th-POK (ZFP-67) Antibody
- 形态：
Th-POK (ZFP-67) Antibody
- 应用范围：
WB, ICC
- 保存条件：
2-8℃
- 浓度：
0.5 mg/ml
- 规格：
100 µg
Purified anti-Th-POK (ZFP-67) Antibody详细如下：
Description ：Th-POK is a member of the BTB-POZ domain-containing zinc finger transcription factor family.It regulates gene expression during intrathymic T cell differentiation. A single autosomalrecessive mutation of the Th-POK gene results in the absence of mature CD4+ helper T cells,called helper-deficient (HD) phenotype. In Th-POK deficient mice, MHC class II restrictedthymocytes are redirected to the CD8+ T cell lineage. On the contrary, forced expression ofTh-POK redirects MHC class I restricted thymocytes to the CD4+ T cell lineage. Inactivation ofTh-POK in mature CD4+ T cells results in induction of the genes preferentially expressed inCD8+ T cells, such as CD8, granzyme B, and IFN-γ. These findings suggest that Th-POK isessential in promoting commitment of immature T cells to the CD4 lineage and maintaining thecharacteristics of mature CD4+ T helper cells.
Verified Reactivity ：Human
Antibody Type ：Monoclonal
Host Species ：Mouse
Immunogen ：Partial human Th-POK recombinant protein (197-345 a.a.)
Formulation ：This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography.
Concentration ：0.5 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C
Application ：WB - Quality tested、ICC - Verified
Recommended Usage ：Each lot of this antibody is quality control tested by Western blotting. For Western blotting, thesuggested use of this reagent is 0.5 - 2.0 µg per ml. For immunocytochemistry, the suggested useof this reagent is 1.0 - 5.0 µg per ml. It is recommended that the reagent be titrated for optimalperformance for each application.
Description ：Th-POK is a member of the BTB-POZ domain-containing zinc finger transcription factor family.It regulates gene expression during intrathymic T cell differentiation. A single autosomalrecessive mutation of the Th-POK gene results in the absence of mature CD4+ helper T cells,called helper-deficient (HD) phenotype. In Th-POK deficient mice, MHC class II restrictedthymocytes are redirected to the CD8+ T cell lineage. On the contrary, forced expression ofTh-POK redirects MHC class I restricted thymocytes to the CD4+ T cell lineage. Inactivation ofTh-POK in mature CD4+ T cells results in induction of the genes preferentially expressed inCD8+ T cells, such as CD8, granzyme B, and IFN-γ. These findings suggest that Th-POK isessential in promoting commitment of immature T cells to the CD4 lineage and maintaining thecharacteristics of mature CD4+ T helper cells.
Verified Reactivity ：Human
Antibody Type ：Monoclonal
Host Species ：Mouse
Immunogen ：Partial human Th-POK recombinant protein (197-345 a.a.)
Formulation ：This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography.
Concentration ：0.5 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C
Application ：WB - Quality tested、ICC - Verified
Recommended Usage ：Each lot of this antibody is quality control tested by Western blotting. For Western blotting, thesuggested use of this reagent is 0.5 - 2.0 µg per ml. For immunocytochemistry, the suggested useof this reagent is 1.0 - 5.0 µg per ml. It is recommended that the reagent be titrated for optimalperformance for each application.
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Purified 抗 Th-POK (ZFP-67) 抗体
￥4500
