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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
齐源
- 库存:
999
- 靶点:
CD283
- 级别:
mouse CD283 (TLR3) Antibody
- 目录编号:
mouse CD283 (TLR3) Antibody
- 克隆性:
单克隆
- 抗原来源:
大鼠
- 保质期:
mouse CD283 (TLR3) Antibody
- 抗体英文名:
anti-mouse CD283 (TLR3) Antibody-APC
- 抗体名:
CD283 (TLR3) Antibody
- 标记物:
APC
- 宿主:
大鼠
- 适应物种:
小鼠
- 免疫原:
mouse CD283 (TLR3) Antibody
- 亚型:
mouse CD283 (TLR3) Antibody
- 形态:
mouse CD283 (TLR3) Antibody
- 应用范围:
ICFC
- 保存条件:
2-8℃
- 浓度:
0.2 mg/ml
- 规格:
25 µg/100 µg
| 规格: | 25 µg | 产品价格: | ¥3000.0 |
|---|---|---|---|
| 规格: | 100 µg | 产品价格: | ¥6100.0 |
Description :Toll-like receptor 3 (TLR3), also known as CD283, is type I transmembrane protein thatbelongs to the TLR family. It forms a large horseshoe shape that contacts a neig-hboringhorseshoe, forming a dimer of two horseshoes. It is characterized by an extracellular domainwith leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor.TLR3 is expressed selectively on the cytoplasmic membrane and intracellularly in dendriticcells. It is also highly expressed in the placenta, pancreas, heart, liver, lung, and muscle. TLR3is a pattern recognition receptor that participates in innate immune response to microbialpathogens by recognizing polyinosine-polycytidylic acid (Poly(I:C)) and dsRNA. Ligand bindingby TLR3 induces receptor dimerization which results in inducing NF-κB activation (via TRIFlinked RIP1/TLR3 interactions) and cytokine production. TLR3 has been shown to interact witha number of proteins including MYD88, TRAF6, TRIAD3, MAP3K7, and TAB2.
Verified Reactivity :Mouse
Antibody Type :Monoclonal
Host Species :Rat
Immunogen :Recombinant mouse TLR3 extracellular domain.
Formulation :Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation :The antibody was purified by affinity chromatography and conjugated with APC under optimalconditions.
Concentration :0.2 mg/ml
Storage & Handling :The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application :ICFC - Quality tested
Recommended Usage :Each lot of this antibody is quality control tested by intracellular immunofluorescent staining withflow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µgper million cells in 100 µl volume. It is recommended that the reagent be titrated for optimalperformance for each application.
Excitation Laser :Red Laser (633 nm)
Application Notes :Additional reported application (for the relevant formats) include: immunohistochemical staining offrozen tissue .
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文献和实验1. McCartney S, et al. 2009. J. Exp. Med. 13:2967. (IHC)
Product Citations:
1. Silver AC, et al. 2018. Heliyon. 4:e00579. PubMed
2. Findlay EG, et al. 2019. Oncoimmunology. 8:1608106. PubMed
3. Qu J, et al. 2018. J Immunol Res. 2018:7519856. PubMed
4. Lopez DA, et al. 2022. Cell Rep. 41:111677. PubMed
5. Takemura R, et al. 2015. Cancer Immunol Res. 3: 902-914. PubMed
6. Berrien–Elliott MM, et al. 2020. Immunity. 51(3):479-490. PubMed
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