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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
CD223
- 级别：
CD223 (LAG-3) Antibody
- 目录编号：
CD223 (LAG-3) Antibody
- 克隆性：
单克隆
- 抗原来源：
小鼠
- 保质期：
CD223 (LAG-3) Antibody
- 抗体英文名：
Dazzle™ 594 anti-human CD223 (LAG-3) Antibody-PE
- 抗体名：
CD223 (LAG-3) Antibody
- 标记物：
PE
- 宿主：
小鼠
- 适应物种：
人
- 免疫原：
CD223 (LAG-3) Antibody
- 亚型：
CD223 (LAG-3) Antibody
- 形态：
CD223 (LAG-3) Antibody
- 应用范围：
FC
- 保存条件：
2-8℃
- 浓度：
CD223 (LAG-3) Antibody
- 规格：
25 tests/100 tests
| 规格： | 25 tests | 产品价格： | ￥2900.0 |
|---|---|---|---|
| 规格： | 100 tests | 产品价格： | ￥7000.0 |
Dazzle™ 594 anti-human CD223 (LAG-3) Antibody-PE详细如下：
Description ：CD223, also known as LAG-3, is a 70 kD type I transmembrane glycoprotein that is involved inT-cell signaling. Similar to CD4, CD223 binds MHC class II, but with a higher affinity. CD223negatively regulates T-cell activation. It is expressed by activated T-cells and natural killer cells(NKs), as well as regulatory T-cells. It is transiently expressed on the surface of activated Tcells in acute conditions but high expression is maintained under tolerizing conditions. CD223deficiency results in reduced tumor growth. CD223 and PD-1 can act in synergy and reverseexhausted phenotypes, improve tumor rejection, and control viral load.
Verified Reactivity ：Human
Antibody Type ：Monoclonal
Host Species ：Mouse
Immunogen ：Human LAG-3 transfected cells
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation ：The antibody was purified by affinity chromatography and conjugated with PE/Dazzle™ 594 underoptimal conditions.
Concentration ：Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysis online tool.)
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application ：FC - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in100 µl staining volume or 5 µl per 100 µl of whole blood.
* PE/Dazzle™ 594 has a maximum excitation of 566 nm and a maximum emission of 610 nm.
Excitation Laser ：Blue Laser (488 nm)、Green Laser (532 nm)、Yellow-Green Laser (561 nm)
Description ：CD223, also known as LAG-3, is a 70 kD type I transmembrane glycoprotein that is involved inT-cell signaling. Similar to CD4, CD223 binds MHC class II, but with a higher affinity. CD223negatively regulates T-cell activation. It is expressed by activated T-cells and natural killer cells(NKs), as well as regulatory T-cells. It is transiently expressed on the surface of activated Tcells in acute conditions but high expression is maintained under tolerizing conditions. CD223deficiency results in reduced tumor growth. CD223 and PD-1 can act in synergy and reverseexhausted phenotypes, improve tumor rejection, and control viral load.
Verified Reactivity ：Human
Antibody Type ：Monoclonal
Host Species ：Mouse
Immunogen ：Human LAG-3 transfected cells
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation ：The antibody was purified by affinity chromatography and conjugated with PE/Dazzle™ 594 underoptimal conditions.
Concentration ：Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysis online tool.)
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application ：FC - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in100 µl staining volume or 5 µl per 100 µl of whole blood.
* PE/Dazzle™ 594 has a maximum excitation of 566 nm and a maximum emission of 610 nm.
Excitation Laser ：Blue Laser (488 nm)、Green Laser (532 nm)、Yellow-Green Laser (561 nm)
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文献和实验该产品被引用文献
Product Citations：
1. Cheng J, et al. 2022. iScience. 25:103588. PubMed
2. Freed-Pastor WA, et al. 2021. Cancer Cell. 39:1342. PubMed
1. Cheng J, et al. 2022. iScience. 25:103588. PubMed
2. Freed-Pastor WA, et al. 2021. Cancer Cell. 39:1342. PubMed
文献支持
Dazzle™ 594 抗人 CD223 (LAG-3) 荧光标记PE 抗体
￥2900 - 7000
