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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
齐源
- 库存:
999
- 靶点:
CD226
- 级别:
CD226 (DNAM-1) Antibody
- 目录编号:
CD226 (DNAM-1) Antibody
- 克隆性:
单克隆
- 抗原来源:
小鼠
- 保质期:
CD226 (DNAM-1) Antibody
- 抗体英文名:
PerCP/Cyanine5.5 anti-human CD226 (DNAM-1) Antibody
- 抗体名:
CD226 (DNAM-1) 抗体
- 标记物:
CD226 (DNAM-1) Antibody
- 宿主:
小鼠
- 适应物种:
人
- 免疫原:
CD226 (DNAM-1) Antibody
- 亚型:
CD226 (DNAM-1) Antibody
- 形态:
CD226 (DNAM-1) Antibody
- 应用范围:
FC
- 保存条件:
2-8℃
- 浓度:
CD226 (DNAM-1) Antibody
- 规格:
25 tests/100 tests
| 规格: | 25 tests | 产品价格: | ¥3000.0 |
|---|---|---|---|
| 规格: | 100 tests | 产品价格: | ¥6500.0 |
Description :DNAM-1 (CD226) is a ~65 kD glycoprotein expressed on cell surface of T cells, NK cells,monocytes/macrophages, platelets and megakaryocytes and a subset of B cells and a memberof the immunoglobulin (Ig)-superfamily containing 2 Ig-like domains of the V-set. The ligandsfor CD226 are the poliovirus receptor (CD155) and its family member nectin-2 (CD112), whichare broadly expressed on epithelial, endothelial and neuronal cells. CD226 is physicallyassociated with LFA-1 in NK cells and activated T cells, and involved in LFA-1-mediatedsignaling.
Verified Reactivity :Human
Reported Reactivity :African Green, Baboon, Cynomolgus, Rhesus
Antibody Type :Monoclonal
Host Species :Mouse
Formulation :Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation :The antibody was purified by affinity chromatography and conjugated with PerCP/Cyanine5.5under optimal conditions.
Concentration :Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysis online tool.)
Storage & Handling :The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application :FC - Quality tested
Recommended Usage :Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in100 µl staining volume or 5 µl per 100 µl of whole blood.
* PerCP/Cyanine5.5 has a maximum absorption of 482 nm and a maximum emission of 690 nm.
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文献和实验1. Fuchs A, et al. 2004. J. Immunol. 172:3994.
Product Citations:
1. Witkowski M, et al. 2021. Nature. 600:295. PubMed
2. Willem C, et al. 2019. J Immunol. 202:2141. PubMed
中科院高福院士课题组 2019 年发表了哪些重要的研究成果?
of the side-by-side two-IgV molecule CD226 /DNAM- 1 to its ligand CD155 /Necl- 5(并排的两个 IgV 分子 CD226 / DNAM- 1 与配体 CD155 / Necl- 5 的结合模式)CD226 /DNAM- 1 是一种在 NK 细胞中表达的刺激分子,它通过与 NK 细胞的配体 CD155 结合来调节 NK 细胞的功能。研究人员通过测定载脂蛋白 CD226 和 CD226 -CD155 复合物的结构,探讨激活受体 CD226 和 CD155 相互作用的分子
删除突变的drs基因分析揭示,C末端区以及3个一致重复的N末端区都出现凋亡。Caspase-12、Caspase –9以及Caspase-3都继续被drs激活,Caspase--3,和Caspase-9的抑制剂都抑制drs引起的凋亡。在凋亡过程中没有看到因drs引起线粒体细胞色素C释放到细胞质去,这表明线粒体途径不是drs介导的凋亡,而且,研究人员发现,Drs蛋白能与定位在内质网的凋亡蛋白ASY/Nogo-B/RTN-x(S)结合,并且这些基因共同表达增加了凋亡的效果。这项研究结果提示,由ASY










