生物素抗人脂联素 (Acrp30) 抗体

Biotin anti-human Adiponectin (Acrp30) Antibody详细如下：

Description ：Adiponectin, also referred as Acrp30, AdipoQ, apM1, and gelatin binding protein of 28 kD(GBP-28), is encoded by the ADIPOQ gene in humans. Adiponectin contains 244 amino acidswith a collagen-like domain at the N-terminal and a globular domain at the C-terminal. Theglobular domain can be proteolytically truncated forming the globular adiponectin(gAdiponectin). This globular domain resembles the structure of the complement C1q and theTNF-α superfamily. Adiponectin exists in a wide range of homo-oligomers: a low-molecularweight (LMW) trimer, a medium molecular weight (MMW) hexamer, and a high molecular weight(HMW) multimer with little or no interconversion between the forms. Females generally havehigher HMW than males in proportion and absolute amounts. Adiponectin has two receptors(adipoRs)-1 and -2. AdipoR1 mRNA is detectable in skeletal muscle, spleen, lung, heart,kidney, and liver. AdipoR2 is expressed in liver, but is also detectable in heart, lung, skeletalmuscle, and kidney.

Adiponectin plays an important role in carbohydrate and lipid metabolism. It promotes insulinsensitivity and protects cells from inflammation and apoptosis. It is also hypothesized to haveanti-atherogenic activity. Normal circulating adiponectin level ranges from 4-30 µg/mL.Adiponectin levels are inversely correlated with body mass index (BMI). Low serum level ofadiponectin is found in obesity, type 2 diabetes and those with coronary artery disease.Therefore, adiponectin serves as an important clinical biomarker for metabolic syndromes.

Verified Reactivity ：Human

Antibody Type ：Monoclonal

Host Species ：Mouse

Immunogen ：Recombinant human Adiponectin

Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide

Preparation ：The antibody was purified by affinity chromatography and conjugated with biotin under optimalconditions.

Concentration ：0.5 mg/ml

Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.

Application ：ELISA Detection - Quality tested

Recommended Usage ：Each lot of this antibody is quality control tested by ELISA assay. For ELISA capture applications, aconcentration range of 0.05-0.2 µg/ml is recommended. To obtain a linear standard curve, serialdilutions of Adiponectin protein ranging from 10,000 to 156 pg/ml are recommended for eachELISA plate. It is recommended that the reagent be titrated for optimal performance for eachapplication.