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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
CD279 (PD-1)
- 级别：
CD279 (PD-1) Antibody
- 目录编号：
CD279 (PD-1) Antibody
- 克隆性：
单克隆
- 抗原来源：
大鼠
- 保质期：
CD279 (PD-1) Antibody
- 抗体英文名：
Dazzle™ 594 anti-mouse CD279 (PD-1) Antibody-PE
- 抗体名：
CD279 (PD-1) Antibody
- 标记物：
PE
- 宿主：
大鼠
- 适应物种：
小鼠
- 免疫原：
CD279 (PD-1) Antibody
- 亚型：
CD279 (PD-1) Antibody
- 形态：
CD279 (PD-1) Antibody
- 应用范围：
FC
- 保存条件：
2-8℃
- 浓度：
0.2 mg/ml
- 规格：
25 µg/100 µg
| 规格： | 25 µg | 产品价格： | ￥2400.0 |
|---|---|---|---|
| 规格： | 100 µg | 产品价格： | ￥5900.0 |
Description ：CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging tothe CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells andthymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyteclonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positiveselection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation isessential for prolonged survival of intratesticular islet allografts.
Verified Reactivity ：Mouse
Antibody Type ：Monoclonal
Host Species ：Rat
Immunogen ：PD-1 cDNA followed by PD-1-Ig fusion protein
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography and conjugated with PE/Dazzle™ 594 underoptimal conditions.
Concentration ：0.2 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application ：FC - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤0.125 µg per millioncells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance foreach application.
* PE/Dazzle™ 594 has a maximum excitation of 566 nm and a maximum emission of 610 nm.
Excitation Laser ：Blue Laser (488 nm)、Green Laser (532 nm)、Yellow-Green Laser (561 nm)
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文献和实验1. Good-Jacobson KL, et al. 2010. Nat. Immunol. 11:535. (FC) PubMed
2. Lázár-Molnár E, et al. 2008. Proc. Natl. Acad. Sci. USA 105:2658. (Block)
3. Liang SC, et al. 2003. Eur. J. Immunol. 33:2706. (FC, IHC, Block)
4. Tobias J, et al. 2020. Front Immunol. 11:895 (FC, ELISA) PubMed
5. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
6. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations：
1. Zhu X, et al. 2017. Arch Oral Biol. 10.1016/j.archoralbio.2017.03.010. PubMed
2. Moon S, et al. 2021. J Exp Med. 218:. PubMed
3. Taylor D, et al. 2022. Front Immunol. 13:936129. PubMed
4. Śledzińska A, et al. 2020. Immunity. 52(1):151-166.e6.. PubMed
5. Velazquez VM, et al. 2017. Mol Ther Methods Clin Dev. 0.277083333. PubMed
6. Wang C, et al. 2018. Sci Transl Med. 10. PubMed
7. Lee A, et al. 2022. Nat Commun. 13:549. PubMed
8. Zhang L, et al. 2021. Mol Ther. 29:744. PubMed
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