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文献和实验α response, we used two human-tumor-derived cell lines: the melanoma line ME-15 (10 ) and the hepatoma line HuH7 (11 ). We have chosen these cell lines as models, because we have a good understanding of the IFNα responses at the mRNA and the protein levels
adrenergic receptor/Arg389Gly MDR1/C3435T il-2 il-4 il-10 TNF alpha IFN gamma hOGG1 bcr\abl human serum albumin VEGF165 GalNacT agouti-related protein, AGRP PAI-1 MDR1 MRP1 OPN U6 Promoter GFP MDR1 exon7~11 MDR1 exon12/14/18/20/22
. However, the IFNα-induced changes detected in our study are relatively small compared to the changes induced by IFNβ in HuH7 cells (9 ). Finally, it is noteworthy that IRmiRs have similar kinetic properties to their mRNA counterparts. miR-10b for instance
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