Human T-Cell Immunoglobulin An

Cell Reports：山东大学马春红团队揭示 Tim-4 在巨噬细胞抗病毒天然免疫和胆固醇稳态调控中的重要作用

为极具前景的抗病毒治疗策略。 免疫检查点 T 细胞免疫球蛋白及黏蛋白-4 (T-cell immunoglobulin and mucin domain-containing protein 4，Tim-4) 主要表达在抗原提呈细胞表面，是维持巨噬细胞稳态和功能的关键分子之一。作为磷脂酰丝氨酸受体，Tim-4 不仅可以促进巨噬细胞对凋亡细胞的吞噬，还能够促进有包膜病毒的入侵过程。另外，Tim-4 的单核苷酸多态性位点与血脂异常和冠心病相关，且 Tim-4 已被鉴定为脂肪组织中餐后胆固醇转运

Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries

Figure 17.4.1 Photograph of a phage ELISA result. Using eight different clones that were isolated with GST‐SrcSH3 domain as the target, 25 µl of culture supernatant were added to pairs of microtiter plate wells containing GST‐SrcSH3 or GST

Spectroscopic Methods for the Determination of Protein Interactions

and characterization of a high‐affinity TATA‐binding protein interaction domain in the N terminus of yeast TAF(II)130. Mol. Cell. Biol. 17:3081‐3093.    Becker, C.F., Hunter, C.L., Seidel, R