Description :CD117 is a 145 kD protein tyrosine kinase also known as c-Kit. It is a receptor for stem cellfactor or c-Kit ligand. CD117 is expressed on pluripotent hematopoietic progenitor cells(approximately 1-4% bone marrow cells), mast cells, and acute myeloid leukemia cells (AML).CD117 binding of c-Kit ligand induces phosphorylation of CD117 and stimulates proliferationand survival of primitive hematopoietic stem cells as well as erythroid-committed and granulomonocytic committed cells.
Verified Reactivity :Human
Reported Reactivity :Cynomolgus, Cow
Antibody Type :Monoclonal
Host Species :Mouse
Immunogen :MOLM-1 megakaryocytic cell line
Formulation :Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation :The antibody was purified by affinity chromatography, and conjugated with PE/Cyanine5 underoptimal conditions.
Concentration :Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentrationand Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling :The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application :FC - Quality tested
Recommended Usage :Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in100 µl staining volume or 5 µl per 100 µl of whole blood.