BioLegend 919405 PE anti-human

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BioLegend 919405 PE anti-human CD243 (ABCB1)
产品简介：
产品品牌：BioLegend
产品货号：919405
产品名称：BioLegend 919405 PE anti-human CD243 (ABCB1)
产品规格：25 tests

产品说明：
Clone   4E3.16 (See other available formats)
Regulatory Status   RUO
Other Names
MDR-1, Multidrug resistance protein 1, P-glycoprotein 1, colchicin sensitivity, doxorubicin resistance
Isotype   Mouse IgG2a

描述
CD243（MDR-1）属于ATP结合盒（ABC）转运蛋白家族。其分子量约为170kD，由两个同源的半部分组成。每一半含有两个疏水性跨膜结构域（TMDs）和两个亲水性核苷酸结合结构域（NBD）。TMDs横跨膜6次，形成一个具有12个跨膜α-螺旋结构的腔室。NBD通过ATP偶联和水解驱动转运过程，位于膜的细胞质表面。CD243通过细胞膜转运各种分子并参与多药耐药性。MDR-1在造血干细胞、T细胞、B细胞和NK细胞以及许多多药耐药肿瘤细胞上表达。CD243与Cavolin、环指蛋白1B、AAP1、p53、孤儿核受体PX和细胞色素P450相互作用。
CD243 (MDR-1) belongs to the ATP binding cassette (ABC) transporter family. With an approximate molecular mass of 170 kD, it consists of two homologous halves. Each half contains two hydrophobic transmembrane domains (TMDs) and two hydrophilic nucleotide binding domains (NBDs). The TMDs span the membrane six times, forming a chamber with a 12 transmembrane α-helix structure. NBDs drive the transport process through ATP coupling and hydrolysis and are located at the cytoplasmic face of the membrane. CD243 transports various molecules across cellular membranes and is involved in multidrug resistance. MDR-1 is expressed on hematopoietic stem cells, T cells, B cells, and NK cells as well as on many multidrug resistant neoplastic cells. CD243 interacts with Caveolin, RING finger protein 1B, AAP1, p53, Orphan nuclear receptor PX, and cytochrome P450.

Product Details
Isotype Contro   lPE Mouse IgG2a, κ Isotype Ctrl (FC)
Verified Reactivity   Human
Antibody Type   Monoclonal
Host Species    Mouse
Immunogen
SW-1573 cells selected by resistance on doxorubicin.

Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.

Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application    FC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Antigen Details
Structure
Member of ABC transporter family with an approximate molecular weight of 170 kD. Consists of two homologous halves, each comprising two hydrophobic transmembrane domains (TMDs) and two hydrophilic nucleotide binding domains (NBDs).

Distribution
Hematopoietic stem cells, T and B cells, natural killer (NK) cells, and many multidrug resistant neoplastic cells.

Function
Transports various molecules across cellular membranes and is involved in multidrug resistance.

Cell Type
B cells, Hematopoietic stem and progenitors, NK cells, T cells
Biology Area    Cancer Biomarkers, Cell Biology, Immunology
Molecular Family    CD Molecules

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