BioLegend 829901 Purified (azi

美国 BioLegend 公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend 虽然成立的时间不长，但它聚集了一批来自 PharMingen 公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。
BioLegend 公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。

BioLegend 829901 Purified (azide-free) anti-TDP43 Phospho (Ser409/410)
产品简介：
产品品牌：BioLegend
产品货号：829901
产品名称：BioLegend 829901 Purified (azide-free) anti-TDP43 Phospho (Ser409/410)
产品规格：100 µL

Clone   1D3/TDP-43 (See other available formats)
Regulatory Status   RUO
Other Names
TAR DNA-binding protein-43, TDP 43, TARDBP, ALS10
Previously   Covance Catalog# SIG-39852
Isotype   Rat IgG2a

描述
TDP43（又名TARDBP）最初被鉴定为一种与HIV-1病毒基因组长末端重复序列中发现的反式激活反应（TAR）序列结合的蛋白质。TDP43含有两个拷贝的~90个氨基酸的RNA识别基序（RRM），存在于许多结合单链RNA的蛋白质中。TDP-43定位于细胞核。在额颞叶变性和肌萎缩侧索硬化症患者中，它不存在于受影响神经元的细胞核中，但它是细胞质泛素阳性包涵体的主要成分。普遍表达。特别是在胰腺、胎盘、肺、生殖道和脾脏中表达较高。ALS和FTLDU患者海马、新皮层和脊髓中的高磷酸化、泛素化和裂解。
TDP43 (aka TARDBP) was originally identified as a protein which binds to the transactivation response (TAR) sequence found in the long terminal repeat of the HIV-1 virus genome. TDP43 contains two copies of a ~90 amino acid RNA recognition motif (RRM) found in many proteins which bind single stranded RNA. TDP-43 localizes to the nucleus. In patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis, it is absent from the nucleus of affected neurons but it is the primary component of cytoplasmic ubiquitin-positive inclusion bodies.  Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen. Hyperphosphorylated, ubiquitinated, and cleaved in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU.

Product Details
Verified Reactivity   Human, Rat
Antibody Type   Monoclonal
Host Species   Rat
Immunogen
This antibody was raised against a phosphopeptide corresponding to: i) the C-terminal domain of human TDP43; and ii) inclusive of phosphorylated serine residues 409 and 410.

Formulation    Phosphate-buffered solution.
Preparation
The antibody was purified by affinity chromatography.
Concentration    1.0 mg/mL

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.

Application    WB - Quality tested
IHC, ICC, ELISA- Reported in the literature, not verified in house

Recommended Usage
Each lot of this antibody is quality control tested by Western blotting.

Antigen Details
Biology Area
Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
Molecular Family    Phospho-Proteins, TDP43

以下是 BioLegend 品牌部分产品，如需其他产品请联系本公司销售。
BioLegend 102007 PE anti-mouse CD25  PC61   50 ug
BioLegend 102008 PE anti-mouse CD25  PC61   200 ug
BioLegend 102011 APC anti-mouse CD25     PC61   25 ug
BioLegend 102015 PE/Cyanine7 anti-mouse CD25   PC61   25 ug
BioLegend 102016 PE/Cyanine7 anti-mouse CD25   PC61   100 ug
BioLegend 102017 Alexa Fluor® 488 anti-mouse CD25  PC61   100 ug
BioLegend 102018 Alexa Fluor® 488 anti-mouse CD25  PC61   25 ug
BioLegend 102019 Alexa Fluor® 647 anti-mouse CD25  PC61   25 ug
BioLegend 102020 Alexa Fluor® 647 anti-mouse CD25  PC61   100 ug
BioLegend 102021 Pacific Blue™ anti-mouse CD25   PC61   25 ug
BioLegend 102024 Alexa Fluor® 700 anti-mouse CD25  PC61   100 ug
BioLegend 102025 APC/Cyanine7 anti-mouse CD25 PC61   25 ug
BioLegend 102028 PerCP anti-mouse CD25   PC61   100 ug
BioLegend 102030 PerCP/Cyanine5.5 anti-mouse CD25 PC61   100 ug
BioLegend 102033 Brilliant Violet 421™ anti-mouse CD25    PC61   125 uL
BioLegend 102034 Brilliant Violet 421™ anti-mouse CD25    PC61   500 uL
BioLegend 102036 Brilliant Violet 605™ anti-mouse CD25    PC61   50 ug
BioLegend 102037 Brilliant Violet 650™ anti-mouse CD25    PC61   125 uL
BioLegend 102038 Brilliant Violet 650™ anti-mouse CD25    PC61   50 ug
BioLegend 102041 Brilliant Violet 510™ anti-mouse CD25    PC61   125 uL
BioLegend 102043 Brilliant Violet 421™ anti-mouse CD25    PC61   50 ug
BioLegend 102048 PE/Dazzle™ 594 anti-mouse CD25    PC61   100 ug